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Assessing the protective effect of Crassocephalum vitellinum against Rifampicin- induced hepatotoxicity in Wistar rats

2022; Makerere University; Volume: 22; Issue: 1 Linguagem: Inglês

10.4314/ahs.v22i1.43

1729-0503

Kenedy Kiyimba, Emmanuel Tiyo Ayikobua, Daniel Chans Mwandah, Samuel Baker Obakiro,

Natural Antidiabetic Agents Studies

Background: Crassocephalum vitellinum is widely used by traditional medical practitioners and local people in East Africa to manage a large number of ailments including hepatitis 1. However, its hepatoprotective effects had not been evaluated prior to this study. The aim of this study was to assess the effect of an ethanolic leaf extract of Crassocephalum vitellinum against rifampicin-induced liver toxicity in Wistar rats. Methods: Increasing doses of an ethanolic leaf extract of C. vitellinum were administered to Wistar rats daily for 35 days, together with rifampicin given orally as suspension. After the treatment period, Assessment of hepatoprotective activity was done by analysis of serum levels of biochemical and histopathological effects on the liver. Results: The results showed that administration of C. vitellinum extract significantly prevented drug- induced increase in serum levels of liver biomarker enzymes and also decreased the hepatocellular necrosis and inflammatory cells infiltration.Conclusion: The plant extract loweres the liver biomarker enzymes (ALT, ALP, AST) and preserves the histomorphology of the hepatocytes which is suggestive that the plant possess hepatoprotective properties. Keywords: Crassocephalum vitellinum; antitubercular drugs; drug-induced hepatotoxicity; hepatoprotective agents.