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Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

2021; Research Square (United States); Linguagem: Inglês

10.21203/rs.3.rs-309746/v1

Aljawharah Alrubayyi, Ester Gea‐Mallorquí, Emma Touizer, Dan Hameiri‐Bowen, Jakub Kopycinski, Bethany Charlton, Natasha Fisher-Pearson, Luke Muir, Annachiara Rosa, Chloë Roustan, Christopher Earl, Peter Cherepanov, Pierre Pellegrino, Laura Waters, Fiona Burns, Sabine Kinloch, Tao Dong, Lucy Dorrell, Sarah Rowland–Jones, Laura E. McCoy, Dimitra Peppa,

Long-Term Effects of COVID-19

Abstract There is an urgent need to understand the nature of immune responses against SARS-CoV-2, to inform risk-mitigation strategies for people living with HIV (PLWH). We show that the majority of PLWH, controlled on ART, mount a functional adaptive immune response to SARS-CoV-2. Humoral and SARS-CoV-2-specific T cell responses are comparable between HIV-positive and negative subjects and persist 5-7 months following predominately mild COVID-19 disease. T cell responses against Spike, Membrane and Nucleocapsid are the most prominent, with SARS-CoV-2-specific CD4 T cells outnumbering CD8 T cells. We further show that the overall magnitude of SARS-CoV-2-specific T cell responses relates to the size of the naive CD4 T cell pool and the CD4:CD8 ratio in PLWH, in whom disparate antibody and T cell responses are observed. These findings suggest that inadequate immune reconstitution on ART, could hinder immune responses to SARS-CoV-2 with implications for the individual management and vaccine effectiveness in PLWH.