Tom N. Grossmann
2020; Wiley; Volume: 59; Issue: 46 Linguagem: Inglês
10.1002/anie.202005712
ISSN1521-3773
Tópico(s)Biotin and Related Studies
ResumoAngewandte Chemie International EditionVolume 59, Issue 46 p. 20274-20274 Author ProfileFree Access Tom N. Grossmann First published: 28 April 2020 https://doi.org/10.1002/anie.202005712AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract “My favorite quote is ‘All models are wrong, but some are useful' … I advise my students to read first and then go to the lab (can save months of work) …” Find out more about Tom Grossmann in his Author Profile. Tom N. Grossmann The author presented on this page has published his 10. article in Angewandte Chemie in the last 10 years: “Constrained Peptides with Fine-Tuned Flexibility Inhibit NF-Y Transcription Factor Assembly”: S. Jeganathan, M. Wendt, S. Kiehstaller, D. Brancaccio, A. Kuepper, N. Pospiech, A. Carotenuto, E. Novellino, S. Hennig, T. N. Grossmann, Angew. Chem. Int. Ed. 2019, 58, 17351; Angew. Chem. 2019, 131, 17512. The work of T. N. Grossmann has been featured on the inside back cover of Angewandte Chemie: “Coiled-Coil Peptide Beacon: A Tunable Conformational Switch for Protein Detection”: C. Mueller, T. N. Grossmann, Angew. Chem. Int. Ed. 2018, 57, 17079; Angew. Chem. 2018, 130, 17325. Date of birth: September 11, 1978 Position: Chair of Biomimetic Chemistry, Vrije Universiteit Amsterdam (The Netherlands) E-mail: t.n.grossmann@vu.nl Homepage: www.grossmannlab.com ORCID: 0000-0003-0179-4116 Education: 2004 Diploma in Chemistry, Humboldt University, Berlin (Germany) 2008 PhD with Oliver Seitz, Humboldt University, Berlin (Germany) 2009–2011 Postdoc with Gregory L. Verdine, Harvard University (USA) Awards: 2016 ERC Starting Grant; 2013 Emmy Noether Research Grant; 2012 Liebig Fellowship Research: Structure-based design of bioactive molecules (peptidomimetics) and chemical engineering of proteins (proteomimetics) Hobbies: Teaching my two little boys all sorts of naughty things My favorite quote is “All models are wrong, but some are useful” by George E. P. Box. I advise my students to read first and then go to the lab (can save months of work). In a spare hour, I used to watch TV, now I'm on twitter (not sure if that's an improvement). I get advice from my wife. My favorite way to spend a holiday is under the sun and near the water (good food helps too). The secret of being a successful scientist is to take the time to think out of the box and to have relaxed discussions with group members. What I appreciate most about my friends is that they still see the 18-year old rebellious me. The natural talent I would like to be gifted with is patience. When I was eighteen I wanted to be an archeologist. If I could be described as an animal it would be a Phorusrhacos. Last time I went to the pub, Sven and Paul got lost. My favorite drink is Tommy's Margarita. If I could be anyone for a day, I would be the first person who made it past the Berlin Wall on November 9, 1989 allowing me to relive this historic moment. My 5 top papers: 1“DNA-Catalyzed Transfer of a Reporter Group”: T. N. Grossmann, O. Seitz, J. Am. Chem. Soc. 2006, 128, 15596. (My first scientific publication, and I am still proud of the catalytic activities we achieved. This paper also reminds me of the phenomenal time I had during my PhD in the group of Oliver Seitz.) 2“Inhibition of Oncogenic Wnt Signaling Through Direct Targeting of β-Catenin”: T. N. Grossmann, J. T. H. Yeh, B. R. Bowman, Q. Chu, R. E. Moellering, G. L. Verdine, Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 17942. (We report the only crystal structure of a Wnt inhibitor in complex with β-catenin so far, enabled by the help of excellent co-workers and a visionary mentor.) 3“Constrained Peptides with Target-Adapted Cross-Links as Inhibitors of a Pathogenic Protein–Protein Interaction”: A. Glas, D. Bier, G. Hahne, C. Rademacher, C. Ottmann, T. N. Grossmann, Angew. Chem. Int. Ed. 2014, 53, 2489; Angew. Chem. 2014, 126, 2522. (The first research paper from my group still influencing our current work. I am grateful to Christian Ottmann for acquainting us to protein X-ray crystallography). 4“Structure-Based Design of Inhibitors of Protein–Protein Interactions: Mimicking Peptide Binding Epitopes”: M. Pelay-Gimeno, A. Glas, O. Koch, T. N. Grossmann, Angew. Chem. Int. Ed. 2015, 54, 8896; Angew. Chem. 2015, 127, 9022. (In the course of writing this Review for Angewandte Chemie, I learned so much that would help us in following projects.) 5“In situ Cyclization of Native Proteins: Structure-Based Design of a Bicyclic Enzyme”: M. Pelay-Gimeno, T. Bange, S. Hennig, T. N. Grossmann, Angew. Chem. Int. Ed. 2018, 57, 11164; Angew. Chem. 2018, 130, 11334. (Combining my two passions—biocompatible reactions and stabilization of protein conformations—opens the door to new protein engineering approaches.) Volume59, Issue46November 9, 2020Pages 20274-20274 ReferencesRelatedInformation
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