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Chinese-herb nephropathy

1999; Elsevier BV; Volume: 354; Issue: 9191 Linguagem: Inglês

10.1016/s0140-6736(05)76720-9

1474-547X

Paul Pui‐Hay But, Shuang‐Cheng Ma,

Garlic and Onion Studies

Graham Lord and colleagues (Aug 7, p 481)1Lord GL Tagore R Cook T Gower P Pusey CD Nephropathy caused by Chinese herbs in the UK..Lancet. 1999; 354: 481Summary Full Text Full Text PDF PubMed Scopus (254) Google Scholar report two cases of nephropathy from ingesting Chinese herbal remedies that were traceable to a derivative of the herb MuTong. The acute toxicity of excessive doses of MuTong has been previously reported in Chinese publications. One woman wanting to promote milk production ate soup containing 70 g MuTong and red beans; she and her father-in-law who also ate the beans developed acute renal failure.2Wu SH Two cases of acute renal failure by MuTong.Jiangsu J Tradit Chin Med. 1964; 354: 12-13Google Scholar Another woman who took a decoction made with 175 g of MuTong also had acute renal failure. None of the patients died. Less fortunate were two men and two women who took decoctions prepared with 50 g, 70 g, 60 g, and 120 g MuTong,3Liu JY Ceng HJ A fatal case of acute renal failure by large doses of MuTong..Chung Kuo Chung Yao Tsa Chih. 1994; 19: 692-693Google Scholar, 4Hong YS Huang YL Wang RJ Large doses of MuTong can cause fatal renal failure..Zhejiang J Trad Chin Med. 1965; 8: 32Google Scholar respectively; they died of renal failure. There is no report on the long-term adverse effects of MuTong, except a case of renalfunction impairment in a man who took ten doses of a decoction containing 25 g of MuTong.5Duan XY Li GY Song KM A case of kidney function impairment by MuTong..Chin J Nephrol. 1992; 8: 53Google Scholar All these cases were probably caused by GuanMuTong, which is derived from Aristolochia manshuriensis. There are some patented Chinese medicines that contain GuanMuTong. Seven of them, for example, are registered in the People's Republic of China Pharmacopoeia, Anyang Jingzhi plaster, Dahuang Qingwei Pills, Daochi pills, Fenqing Wulin pills, Fuke Fenqing pills, Longdan Xiegan pills, and Xiao'er Jindan tablets. Priority should be given to review of the long-term safety of these products, and GuanMuTong should be excluded from further use. Other sources of MuTong, for example ChuanMuTong from Clematis armata and C montana, which do not contain aristolochic acids, could be used instead.