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Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

2020; Cell Press; Volume: 32; Issue: 3 Linguagem: Inglês

10.1016/j.cmet.2020.07.015

1932-7420

Ana Campos Codo, Gustavo Gastão Davanzo, Lauar de Brito Monteiro, Gabriela Fabiano de Souza, Stéfanie Primon Muraro, João Victor Virgílio-da-Silva, Juliana Silveira Prodonoff, Victor Corasolla Carregari, Carlos Alberto Oliveira de Biagi, Fernanda Crunfli, Jeffersson Leandro Jimenez Restrepo, Pedro Henrique Vendramini, Guilherme Reis‐de‐Oliveira, Karina Bispo-dos-Santos, Daniel A. Toledo-Teixeira, Pierina Lorencini Parise, Matheus Cavalheiro Martini, Rafael Elias Marques, Helison Rafael Pereira do Carmo, Alexandre Borin, Laís D. Coimbra, Vinícius Boldrini, Natália S. Brunetti, André Schwambach Vieira, Eli Mansour, Raisa G. Ulaf, Ana Flávia Bernardes, Thyago A. Nunes, Luciana Cisoto Ribeiro, André C. Palma, Marcus V. Agrela, Maria Luíza Moretti, Andrei C. Spósito, Fabrício Bíscaro Pereira, Lı́cio A. Velloso, Marco Aurélio Ramirez Vinolo, André Damásio, José Luiz Proença‐Módena, Robson Francisco Carvalho, Marcelo A. Mori, Daniel Martins‐de‐Souza, Helder I. Nakaya, Alessandro S. Farias, Pedro M. Moraes‐Vieira,

Diabetes and associated disorders

(Cell Metabolism 32, 437–446.e1–e5; September 1, 2020) In the originally published version of this article, Figure 1E was mistakenly inserted as Figure 1D, and the y axis label was missing in Figure 1C. In addition, some of the representative dot plots of PD-1 expression in gated CD4 T cells in Figure 4C were mistakenly duplicated during editing. These corrections have now been made online. The authors apologize for this error.Figure 1. SARS-CoV-2 Infection Induces Glycolysis in Human Monocytes (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 4C. Monocyte Metabolism Modulates T Cell and Epithelial Cell Response to SARS-CoV-2 (corrected)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 4C. Monocyte Metabolism Modulates T Cell and Epithelial Cell Response to SARS-CoV-2 (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent AxisCodo et al.Cell MetabolismJuly 17, 2020In BriefDiabetic people with uncontrolled blood glucose levels have a greater risk to develop severe COVID-19 disease. Codo et al. show that elevated glucose levels and glycolysis promote SARS-CoV-2 (CoV-2) replication and cytokine production in monocytes through a mitochondrial ROS/hypoxia-inducible factor-1α dependent pathway, resulting in T cell dysfunction and epithelial cell death. Full-Text PDF Open Archive