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Increased Serum Lipoprotein(a) Levels in Patients with Early Renal Failure

1999; American College of Physicians; Volume: 130; Issue: 12 Linguagem: Inglês

10.7326/0003-4819-130-12-199906150-00026

1539-3704

Leonardo A. Sechi,

Blood Coagulation and Thrombosis Mechanisms

Letters15 June 1999Increased Serum Lipoprotein(a) Levels in Patients with Early Renal FailureLeonardo A. Sechi, MD, Laura Zingaro, MD, and Ettore Bartoli, MDLeonardo A. Sechi, MDUniversity of Udine School of Medicine; 33100 Udine, Italy (Sechi)University of Udine School of Medicine; 33100 Udine, Italy (Zingaro)University of Udine School of Medicine; 33100 Udine, Italy (Bartoli)Search for more papers by this author, Laura Zingaro, MDUniversity of Udine School of Medicine; 33100 Udine, Italy (Sechi)University of Udine School of Medicine; 33100 Udine, Italy (Zingaro)University of Udine School of Medicine; 33100 Udine, Italy (Bartoli)Search for more papers by this author, and Ettore Bartoli, MDUniversity of Udine School of Medicine; 33100 Udine, Italy (Sechi)University of Udine School of Medicine; 33100 Udine, Italy (Zingaro)University of Udine School of Medicine; 33100 Udine, Italy (Bartoli)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-12-199906150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Both Elisaf and colleagues and Dr. De Lima report data that confirm elevation of serum Lp(a) levels in patients with early renal failure. Other groups have also reported similar data on patients with renal failure treated conservatively (1, 2). Elisaf and colleagues noted similar frequency distribution of apolipoprotein(a) isoforms in patients with normal and moderately impaired renal function. This finding is consistent with our observations. They also showed that serum Lp(a) levels are significantly increased only in the patients expressing the high-molecular-weight apolipoprotein(a) isoforms, whereas the patients expressing low-molecular-weight isoforms have Lp(a) levels similar to those in persons ...References1. Arnadottir M, Thysell H, Nilsson-Ehle P. Serum lipoprotein(a) concentration is increased in moderate renal failure. Nephron. 1996;72:712-3. CrossrefMedlineGoogle Scholar2. Monzani G, Bergesio F, Ciuti R, Ciciani AM, Martinelli F, Rosati A, et al . Lp(a) levels: effects of progressive chronic renal failure and dietary manipulation. J Nephrol. 1997;10:41-5. MedlineGoogle Scholar3. Sechi LA, Kronenberg F, De Carli S, Falleti E, Zingaro L, Catena C, et al . Association of lipoprotein(a) levels and apolipoprotein(a) size polymorphism with target-organ damage in arterial hypertension. JAMA. 1997;277:1689-95. CrossrefMedlineGoogle Scholar4. Kronenberg F, Utermann G, Dieplinger H. Lipoprotein(a) in renal disease. Am J Kidney Dis. 1996;27:1-25. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Leonardo A. Sechi, MD; Laura Zingaro, MD; Ettore Bartoli, MDAffiliations: University of Udine School of Medicine; 33100 Udine, Italy (Sechi)University of Udine School of Medicine; 33100 Udine, Italy (Zingaro)University of Udine School of Medicine; 33100 Udine, Italy (Bartoli) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIncreased Serum Lipoprotein(a) Levels in Patients with Early Renal Failure Leonardo A. Sechi , Laura Zingaro , Stefano De Carli , Giovanni Sechi , Cristiana Catena , Edmondo Falleti , Elisabetta Dell'Anna , and Ettore Bartoli Increased Serum Lipoprotein(a) Levels in Patients with Early Renal Failure Moses S. Elisaf , Haralampos J. Millionis , and Kostas C. Siamopoulos Increased Serum Lipoprotein(a) Levels in Patients with Early Renal Failure José J.G. De Lima Metrics Cited byCardiovascular disease among patients with type 2 diabetes: role of homocysteine as an inflammatory marker 15 June 1999Volume 130, Issue 12Page: 1028-1029KeywordsCreatininePhenotypesRenal analysisRenal diseasesRenal failureResearch designSerum proteinsStatistical distributions ePublished: 15 August 2000 Issue Published: 15 June 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...