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ESTROGENIC POTENCY OF EFFLUENT FROM TWO SEWAGE TREATMENT WORKS IN THE UNITED KINGDOM

1999; Wiley; Volume: 18; Issue: 5 Linguagem: Inglês

10.1897/1551-5028(1999)018 2.3.co;2

1552-8618

Jule E. Harries, Afsaneh Janbakhsh, Susan Jobling, Peter Matthiessen, John P. Sumpter, Charles R. Tyler,

Pharmaceutical and Antibiotic Environmental Impacts

Environmental Toxicology and ChemistryVolume 18, Issue 5 p. 932-937 Environmental Toxicology Estrogenic potency of effluent from two sewage treatment works in the United Kingdom Jule E. Harries, Corresponding Author Jule E. Harries [email protected] Department of Biology and Biochemistry, Brunel University, Uxbridge, Middlesex, UB8 3PH, United KingdomDepartment of Biology and Biochemistry, Brunel University, Uxbridge, Middlesex, UB8 3PH, United KingdomSearch for more papers by this authorAfsaneh Janbakhsh, Afsaneh Janbakhsh Essex&Suffolk Water, Central Laboratory, Hanningfield Treatment Works, South Hanningfield, Essex, CM3 5HS, United KingdomSearch for more papers by this authorSusan Jobling, Susan Jobling Department of Biology and Biochemistry, Brunel University, Uxbridge, Middlesex, UB8 3PH, United KingdomSearch for more papers by this authorPeter Matthiessen, Peter Matthiessen CEFAS, Burnham Laboratory, Remembrance Avenue, Burnham-on-Crouch, Essex, CMO 8HA, United KingdomSearch for more papers by this authorJohn P. Sumpter, John P. Sumpter Department of Biology and Biochemistry, Brunel University, Uxbridge, Middlesex, UB8 3PH, United KingdomSearch for more papers by this authorCharles R. Tyler, Charles R. Tyler Department of Biology and Biochemistry, Brunel University, Uxbridge, Middlesex, UB8 3PH, United KingdomSearch for more papers by this author Jule E. Harries, Corresponding Author Jule E. Harries [email protected] Department of Biology and Biochemistry, Brunel University, Uxbridge, Middlesex, UB8 3PH, United KingdomDepartment of Biology and Biochemistry, Brunel University, Uxbridge, Middlesex, UB8 3PH, United KingdomSearch for more papers by this authorAfsaneh Janbakhsh, Afsaneh Janbakhsh Essex&Suffolk Water, Central Laboratory, Hanningfield Treatment Works, South Hanningfield, Essex, CM3 5HS, United KingdomSearch for more papers by this authorSusan Jobling, Susan Jobling Department of Biology and Biochemistry, Brunel University, Uxbridge, Middlesex, UB8 3PH, United KingdomSearch for more papers by this authorPeter Matthiessen, Peter Matthiessen CEFAS, Burnham Laboratory, Remembrance Avenue, Burnham-on-Crouch, Essex, CMO 8HA, United KingdomSearch for more papers by this authorJohn P. Sumpter, John P. Sumpter Department of Biology and Biochemistry, Brunel University, Uxbridge, Middlesex, UB8 3PH, United KingdomSearch for more papers by this authorCharles R. Tyler, Charles R. Tyler Department of Biology and Biochemistry, Brunel University, Uxbridge, Middlesex, UB8 3PH, United KingdomSearch for more papers by this author First published: 02 November 2009 https://doi.org/10.1002/etc.5620180517Citations: 114Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Rainbow trout were exposed for 3 weeks (in a flow-through system) to various dilutions of treated effluent (25, 50, 75, and 100%) from Harpenden and Chelmsford sewage treatment works (STW) during November 1994 and August 1996, respectively, and the induction of plasma vitellogenin was measured. Significant (p < 0.05) increases in plasma vitellogenin concentrations occurred in fish held in effluent from Harpenden STW at concentrations of 50% and above. At Chelmsford STW, the effluent appeared to be more potent, causing induction of vitellogenin in fish at concentrations as low as 25% (compared with 50% for the Harpenden effluent). Exposure to lower concentrations of effluent emanating from Chelmsford in April of the following year indicated that estrogenic activity was diluted to no-effect levels at this STW at concentrations between 12 and 25%. References 1 Munkittrick KR, Van Der Kraak GJ, McMaster ME, Portt CB. 1992. 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