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Characterization of OXA-181, a Carbapenem-Hydrolyzing Class D β-Lactamase from Klebsiella pneumoniae

2011; American Society for Microbiology; Volume: 55; Issue: 10 Linguagem: Inglês

10.1128/aac.00481-11

1098-6596

Anaïs Potron, Patrice Nordmann, Emilie Lafeuille, Zaina Al Maskari, Fatma Al Rashdi, Laurent Poirel,

Bacterial Genetics and Biotechnology

ABSTRACT Klebsiella pneumoniae KP3 was isolated from a patient transferred from India to the Sultanate of Oman. K. pneumoniae KP3 was resistant to all β-lactams, including carbapenems, and expressed the carbapenem-hydrolyzing β-lactamase OXA-181, which differs from OXA-48 by four amino acid substitutions. Compared to OXA-48, OXA-181 possessed a very similar hydrolytic profile. The bla OXA-181 gene was located on a 7.6-kb ColE-type plasmid and was linked to the insertion sequence IS Ecp1 . The IS Ecp1 -mediated one-ended transposition of bla OXA-181 was also demonstrated.