Portal de Periódicos da CAPES

Visceral Leishmaniasis (Kala-Azar) Outbreak in Somali Refugees and Kenyan Shepherds, Kenya

2001; Centers for Disease Control and Prevention; Volume: 7; Issue: 3A Linguagem: Inglês

10.3201/eid0703.010346

1080-6059

Günter Boussery,

Environmental and Biological Research in Conflict Zones

To the Editor: A sharp increase in suspected visceral leishmaniasis (VL or kala-azar) cases was reported in April through May 2000 in three Kenyan refugee camps (Ifo, Dagahaley, and Hagadera).Located around Dadaab town in Northeastern Province, the three camps house an estimated 125,000 Somali refugees.VL outbreaks have been well documented in five distinct foci in Kenya (1,2), but until this outbreak, VL was only sporadically seen in the refugee camps or the province.We investigated a possible outbreak in the refugee sites.Before April 2000, doctors would request a formol-gel test (FGT) in case of suspected VL and treat an FGTpositive case with antimonials.Although the FGT is of uncertain validity, it is still used in district hospitals in Kenya for lack of alternative diagnostic tests.We considered a clinician's request of an FGT as a proxy for "clinical VL suspicion" and assessed the number of FGTs done from January 1999 to March 31, 2000.The first suspected VL patient was traced back to August 1999; this 40-year-old male Somali refugee had been ill for 8 months and sought treatment at Dagahaley camp.He responded well to antimonial treatment.From that date to April 1, 2000, an FGT was requested for five more patients; results were positive for two.Specific surveillance for VL was set up by the refugee health services in April 2000.Suspected patients or their caretakers were interviewed.Finger-prick blood was collected on filter paper and analyzed by direct agglutination test (DAT) (3).In August 2000, splenic aspirates were performed on eight patients for direct microscopic examination, and parasite culture was attempted for three specimens.In vitro isolation and gp63 polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) molecular typing was done at the Protozoology Unit of the Prince Leopold Institute of Tropical Medicine in Antwerp, Belgium.Serologically or parasitologically confirmed cases were given stibogluconate (Pentostam), 20 mg/kg/day, for 28 days.We reviewed surveillance data for the period April 1-August 31, 2000, and interviewed the health staff.For case classification, a probable case of VL was illness in a patient with 1) a fever of >2 weeks' duration, 2) splenomegaly or wasting, and 3) positive DAT serology.A confirmed case had these clinical signs, as well as a positive parasitology smear or culture.From April 2000 to August 31, 2000, 26 probable (DAT-positive) VL cases were observed and 8 others were confirmed parasitologically.Gp63 PCR-RFLP molecular typing showed Leishmania donovani in one specimen.The case-fatality rate was 10 (29.4%) of 34 patients in the group of probable and confirmed VL cases.Six deaths occurred before treatment could be started, and one was a complication of the diagnostic procedure (spleen aspirate).Thirty-two interviews were completed in the group of 34 probable or confirmed VL patients.Median age was 15 years, and 8 (25) of the 32 were female.Median delay between onset of symptoms and date of diagnosis was 8 months.Six were Kenyan citizens, five of them shepherds who were grazing their cattle in the area around Dadaab.Of the Somali refugees, seven had been living for >2 years