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New potential markers for cartilage degradation of the knee joint

2002; Taylor & Francis; Volume: 31; Issue: 3 Linguagem: Inglês

10.1080/rhe.31.3.151.157

1502-7732

B. Schmidt-Rohlfing, Karsten Gavénis, Martin Kippels, Ulrich Schneider,

Antimicrobial Peptides and Activities

Objective: To determine the correlation of biochemical markers with the degree of cartilage degradation. Methods: In a cross-sectional study, synovial fluid samples were obtained from 65 patients with cartilage lesions of the knee joint. The measured biochemical markers included MMP-1, MMP-3, and MMP-13, the tissue inhibitor of MMPs (TIMP-1), COMP, YKL-40, and tenascin. The marker levels were compared with the Outerbridge and the Noyes classification. Results: For the majority of markers, the correlation coefficient was below r = 0.3. The highest correlation coefficients were obtained from tenascin (r = 0.66 and 0.67) and MMP-13 (r = 0.44 and 0.41). Conclusion: The overall results indicate that the majority of the tested markers is unspecific with regard to the different stages of the two classifications. However, tenascin and MMP-13 could be of clinical importance to indicate advanced stages. Yet the values of these markers in longitudinal studies are not known.