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Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19

2021; Massachusetts Medical Society; Volume: 385; Issue: 9 Linguagem: Inglês

10.1056/nejmoa2103417

1533-4406

Ewan C. Goligher, Charlotte Bradbury, Bryan J. McVerry, Patrick R. Lawler, Jeffrey S. Berger, Michelle N. Gong, Marc Carrier, Harmony R. Reynolds, Anand Kumar, Alexis F. Turgeon, Lucy Z. Kornblith, Susan R. Kahn, John C. Marshall, Keri S. Kim, Brett L. Houston, Lennie Derde, Mary Cushman, Tobias Tritschler, Derek Angus, Lucas C. Godoy, Zoe McQuilten, Bridget‐Anne Kirwan, Michael E. Farkouh, Maria M. Brooks, Roger Lewis, Lindsay R. Berry, Elizabeth Lorenzi, Anthony Gordon, Tania Ahuja, Farah Al-Beidh, Djillali Annane, Yaseen M. Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H. Billett, Lindsay Bond, Marc J. M. Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A. Castellucci, Sweta Chekuri, Jen‐Ting Chen, Allen C. Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Aira Contreras, Todd W. Costantini, Sophie de Brouwer, Michelle A. Detry, Abhijit Duggal, Vladimír Džavík, Mark B. Effron, Heather Eng, Jorge Escobedo, Lise J Estcourt, Brendan M. Everett, Dean Fergusson, Mark Fitzgerald, Robert Fowler, Joshua D. Froess, Zhuxuan Fu, J.‐P. Galanaud, Benjamin Galen, Sheetal Gandotra, Timothy D. Girard, Andrew L. Goodman, Herman Goossens, Cameron Green, Yonatan Greenstein, Peter L. Gross, Rashan Haniffa, Sheila M. Hegde, Carolyn M. Hendrickson, Alisa M. Higgins, Alexander Hindenburg, Aluko A. Hope, James M Horowitz, Christopher M. Horvat, David T. Huang, Kristin Hudock, Beverley J. Hunt, Mansoor Husain, Robert C. Hyzy, Jeffrey R. Jacobson, Devachandran Jayakumar, Norma Keller, Akram Khan, Yuri Kim, Andrei Kindzelski, Andrew J. King, M. Margaret Knudson, Aaron E. Kornblith, Matthew Kutcher, Michael Laffan, François Lamontagne, Grégoire Le Gal, Christine M. Leeper, Eric Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, José López‐Sendón, Sylvain Lother, Nicole Marten, Andréa Saud Marinez, Mary Martinez, Eduardo Mateos Garcia, Stavroula Mavromichalis, Daniel F. McAuley, Emily G. McDonald, Anna McGlothlin, Shay McGuinness, Saskia Middeldorp, Stephanie K. Montgomery, Paul Mouncey, Srinivas Murthy, Girish B. Nair, Rahul Nair, Alistair Nichol, José Carlos Nicolau, Brenda Nunez‐Garcia, John J. Park, Pauline K. Park, Rachael Parke, Rachael Parke, Sam Parnia, Jonathan Paul, Mauricio Pompilio, John G. Quigley, Robert S Rosenson, Natalia S Rost, Kathy Rowan, Fernanda O Santos, Marlene Santos, Mayler Olombrada Nunes de Santos, Lewis Satterwhite, Christina Saunders, Jake Schreiber, Roger Schutgens, Christopher W. Seymour, Deborah Siegal, Delcio G Silva, Aneesh B. Singhal, Arthur S. Slutsky, Dayna Solvason, Simon Stanworth, Anne Turner, Wilma van Bentum-Puijk, Frank L. van de Veerdonk, Sean van Diepen, Gloria Vázquez‐Grande, Lana Wahid, Vanessa Wareham, R. Jay Widmer, Jennifer G. Wilson, Eugene Yuriditsky, Yongqi Zhong, Scott Berry, Colin J McArthur, Matthew D. Neal, Judith S. Hochman, Steven A. Webb, Ryan Zarychanski,

COVID-19 and healthcare impacts

Thrombosis and inflammation may contribute to morbidity and mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in critically ill patients with Covid-19.