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Copper( I ) ‐ Catalyzed Asymmetric Hydrosilylations of Imines at Ambient Temperatures

2004; Wiley; Volume: 116; Issue: 17 Linguagem: Inglês

10.1002/ange.200353294

1521-3757

Bruce H. Lipshutz, Hideo Shimizu,

Catalytic C–H Functionalization Methods

Angewandte ChemieVolume 116, Issue 17 p. 2278-2280 Zuschrift Copper(I)-Catalyzed Asymmetric Hydrosilylations of Imines at Ambient Temperatures† Bruce H. Lipshutz Prof., Bruce H. Lipshutz Prof. lipshutz@chem.ucsb.edu Department of Chemistry, University of California, Santa Barbara, CA 93106, USA, Fax: (+1) 805-893-8265Search for more papers by this authorHideo Shimizu, Hideo Shimizu Department of Chemistry, University of California, Santa Barbara, CA 93106, USA, Fax: (+1) 805-893-8265Search for more papers by this author Bruce H. Lipshutz Prof., Bruce H. Lipshutz Prof. lipshutz@chem.ucsb.edu Department of Chemistry, University of California, Santa Barbara, CA 93106, USA, Fax: (+1) 805-893-8265Search for more papers by this authorHideo Shimizu, Hideo Shimizu Department of Chemistry, University of California, Santa Barbara, CA 93106, USA, Fax: (+1) 805-893-8265Search for more papers by this author First published: 16 April 2004 https://doi.org/10.1002/ange.200353294Citations: 60 † We thank the NSF (CHE 0213522) for financial support, and Takasago for a research assistantship to H.S. We are also indebted to Dr. Takao Saito (Takasago), Drs. Rudolf Schmid and Michelangelo Scalone (Roche), Drs. Hans-Ulrich Blaser and Marc Thommen (Solvias) for supplying the SEGPHOS, BIPHEP, and JOSIPHOS ligands, respectively, used in this study. Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Suchen sie eine einfache Methode zum enantioselektiven Aufbau benzylischer Stereozentren mit Stickstoffsubstituenten? Dann ziehen Sie folgende bequeme Alternative zur asymmetrischen Hydrierung in Betracht: Die Kombination aus CuH und einem enantiomerenreinen segphos-Liganden katalysiert die Reduktion von Arylketiminen bei Raumtemperatur in hohen Ausbeuten und mit ee-Werten (siehe Schema; TMDS=Tetramethyldisiloxan). Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2004/z53294_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume116, Issue17April 19, 2004Pages 2278-2280 This is the German version of Angewandte Chemie. Note for articles published since 1962: Do not cite this version alone. Take me to the International Edition version with citable page numbers, DOI, and citation export. We apologize for the inconvenience. RelatedInformation