The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53
2005; Cell Press; Volume: 8; Issue: 2 Linguagem: Inglês
10.1016/j.ccr.2005.07.007
ISSN1878-3686
AutoresHiroaki Higashitsuji, Hisako Higashitsuji, Katsuhiko Itoh, Toshiharu Sakurai, Toshikazu Nagao, Yasuhiko Sumitomo, Tomoko Masuda, Simon Dawson, Yutaka Shimada, R. John Mayer, Jun Fujita,
Tópico(s)Epigenetics and DNA Methylation
ResumoIn this article (Cancer Cell 8, pp. 75–86), the name of one of the authors was listed incorrectly. The author incorrectly listed as “Haruhiko Sumitomo” is actually named Yasuhiko Sumitomo. The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53Higashitsuji et al.Cancer CellJuly, 2005In BriefGankyrin is an ankyrin repeat oncoprotein commonly overexpressed in hepatocellular carcinomas. Gankyrin interacts with the S6 proteasomal ATPase and accelerates the degradation of the tumor suppressor Rb. We show here that gankyrin has an antiapoptotic activity in cells exposed to DNA damaging agents. Downregulation of gankyrin induces apoptosis in cells with wild-type p53. In vitro and in vivo experiments revealed that gankyrin binds to Mdm2, facilitating p53-Mdm2 binding, and increases ubiquitylation and degradation of p53. Full-Text PDF Open Archive
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