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An Improved Implementation of Codon Adaptation Index

2007; SAGE Publishing; Volume: 3; Linguagem: Inglês

10.1177/117693430700300028

1176-9343

Xuhua Xia,

Genomics and Phylogenetic Studies

Codon adaptation index is a widely used index for characterizing gene expression in general and translation efficiency in particular. Current computational implementations have a number of problems leading to various systematic biases. I illustrate these problems and provide a better computer implementation to solve these problems. The improved CAI can predict protein production better than CAI from other commonly used implementations.