Produção Nacional
Revisado por pares
Heterogeneity of mitochondrial DNA haplotypes in Pre‐Columbian natives of the Amazon region
1996; Wiley; Volume: 101; Issue: 1 Linguagem: Inglês
10.1002/(sici)1096-8644(199609)101
ISSN1096-8644
AutoresÂndrea Ribeiro‐dos‐Santos, Sidney Santos, Ana Lúcia Machado, Vera Guapindaia, Marco A. Zago,
Tópico(s)Forensic Anthropology and Bioarchaeology Studies
ResumoAmerican Journal of Physical AnthropologyVolume 101, Issue 1 p. 29-37 Token Access Heterogeneity of mitochondrial DNA haplotypes in Pre-Columbian natives of the Amazon region Andrea K. C. Ribeiro-Dos-Santos, Andrea K. C. Ribeiro-Dos-Santos Department of Pathology, Federal University of Pará, 66000 Belém, BrazilSearch for more papers by this authorSidney E. B. Santos, Sidney E. B. Santos Department of Pathology, Federal University of Pará, 66000 Belém, BrazilSearch for more papers by this authorAna Lucia Machado, Ana Lucia Machado Museu Paraense Emílio Goeldi, 66000 Belém, BrazilSearch for more papers by this authorVera Guapindaia, Vera Guapindaia Museu Paraense Emílio Goeldi, 66000 Belém, BrazilSearch for more papers by this authorMarco A. Zago, Corresponding Author Marco A. Zago Department of Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900 Ribeirão Preto, BrazilDepartment of Medicine, Faculty of Medicine, 14049-900 Ribeirão Preto, BrazilSearch for more papers by this author Andrea K. C. Ribeiro-Dos-Santos, Andrea K. C. Ribeiro-Dos-Santos Department of Pathology, Federal University of Pará, 66000 Belém, BrazilSearch for more papers by this authorSidney E. B. Santos, Sidney E. B. Santos Department of Pathology, Federal University of Pará, 66000 Belém, BrazilSearch for more papers by this authorAna Lucia Machado, Ana Lucia Machado Museu Paraense Emílio Goeldi, 66000 Belém, BrazilSearch for more papers by this authorVera Guapindaia, Vera Guapindaia Museu Paraense Emílio Goeldi, 66000 Belém, BrazilSearch for more papers by this authorMarco A. Zago, Corresponding Author Marco A. Zago Department of Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900 Ribeirão Preto, BrazilDepartment of Medicine, Faculty of Medicine, 14049-900 Ribeirão Preto, BrazilSearch for more papers by this author First published: September 1996 https://doi.org/10.1002/(SICI)1096-8644(199609)101:1 3.0.CO;2-8Citations: 42AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract We report the first study of mitochondrial DNA (mtDNA) sequencing from ancestral Amerindian populations of the South American continent. Sequencing of the D-loop region of mtDNA was carried out for bone fragments from 18 skeletons of Pre-Columbian Amerinidians. The skeletons were excavated in different archeological sites of the Brazilian Amazon region, with dating estimated at 500–4,000 years before the present. The sequencing of at least 354 bases permitted the identification of 13 haplotypes defined by variation of 26 nucleotide positions. Two haplotypes were shared by more than one sample, while 11 haplotypes were observed for a single sample. Seven haplotypes observed in 11 individuals (61% of the sample) belong to the four haplogroups described by Horai et al. (1993). Three samples that shared the transition C → T in positions 16,223 and 16,278 formed a fifth haplogroup, which has been previously described in present-day Indian populations. Finally, four samples formed a heterogeneous group but each haplotype had at least one mutation typically detected in Asian or Mongoloid populations. Thus, although only haplotypes shared by Asian populations were detected, a wide haplotype variability was observed. If our sample is representative of Pre-Columbian South America, the percentage of haplotypes (39%) not belonging to the four haplogroups described by Horai is much greater than in contemporary indigenous populations. This permits us to suggest that, in addition to the postulated bottleneck effect during the migration from Asia to the Americas, the depopulation effect started by European colonization in the 16th century contributed to the reduction in genetic variability of Amerindians. © 1996 Wiley-Liss, Inc. Citing Literature Volume101, Issue1September 1996Pages 29-37 RelatedInformation
Referência(s)