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Follicular lymphoma triggers phenotypic and functional remodeling of the human lymphoid stromal cell landscape

2021; Cell Press; Volume: 54; Issue: 8 Linguagem: Inglês

10.1016/j.immuni.2021.07.018

1097-4180

Frédéric Mourcin, Léa Verdiére, David Roulois, Rada Amin, Claire Lamaison, Vonick Sibut, Brice Thamphya, Céline Pangault, Céline Monvoisin, Sarah Huet, Marine Seffals, Sylvain Baulande, Fatima Mechta‐Grigoriou, Patricia Legoix, Delphine Rossille, Marion Guirriec, Simon Léonard, Guillaume Cartron, Gilles Salles, Thierry Fest, Karin Tarte,

Cutaneous lymphoproliferative disorders research

(Immunity 54, 1788–1806.e1–e8; August 10, 2021) In the originally published article, the authors incorrectly identified human Podoplanin (PDPN) as Gp38. gp38 is an alias for murine podoplanin (Pdpn) protein based on its molecular weight of 38 kDa. However, the molecular weight of human PDPN is 36 kDa. This nomenclature error has since been corrected online to where the recommended protein names of PDPN and Pdpn are now used for human and murine datasets, respectively, throughout the manuscript. This is consistent with the approved gene names for these proteins. The authors confirm that this change does not affect any data or conclusions in the study and apologize for any confusion that may have been caused. Follicular lymphoma triggers phenotypic and functional remodeling of the human lymphoid stromal cell landscapeMourcin et al.ImmunityJune 23, 2021In BriefLymphoid stromal cells (LSCs) regulate adaptive immune response dynamics, but their classification in humans is not well described. Mourcin et al. decipher the phenotypic, transcriptomic, and functional landscape of healthy human LSCs. In follicular lymphoma, bidirectional crosstalk with immune cells is shown to reprogram LSCs into tumor-supportive stromal cells. Full-Text PDF