Aminoglutethimide
1986; Elsevier BV; Linguagem: Inglês
10.1016/s0099-5428(08)60412-8
ISSN2163-5846
Autores Tópico(s)Analytical Chemistry and Chromatography
ResumoThis chapter discusses aminoglutethimide. Aminoglutethimide was initially developed as an anticonvulsant in the 1950s but was later withdrawn from clinical use after reports of adrenal in sufficiency. Aminoglutethimide inhibits steroid aromatase enzyme involved in the biosynthesis of estrogens. It is currently used as an effective agent for the treatment of advanced breast cancer in post-menopausal women. It is white to creamy white crystalline powder, odorless and possessing a bitter taste. It is virtually insoluble in water, freely soluble in most organic solvents, for example, methanol, methylene chloride, and chloroform. The ultraviolet spectrum of aminoglutethimide in neutral methanol is explored in this chapter. It exhibits a maximum at about 242 nm and a shoulder at approximately 282 nm. The maxima at 242 and 282 nm do not change or shift in acidic or basic media. The mass spectrum of aminoglutethimide obtained by chemical ionization (CI) on a solid probe using CH4 as ionizing gas is explored in the chapter.
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