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Diphenhydramine Hydrochloride

1974; Elsevier BV; Linguagem: Inglês

10.1016/s0099-5428(08)60068-4

2163-5846

Ira J. Holcomb, Salvatore A. Fusari,

Analytical Methods in Pharmaceuticals

Diphenhydramine hydrochloride is 2- (dipheny1methoxy)-N,N-dimethylethylamine hydrochloride -1 Six additional chemical names are listed in The Merck Index, along with twelve trade names. One additional name is Dimedrol. Diphenhydramine hydrochloride is a white, odorless, crystalline powder. Diphenhydramine hydrochloride is not optically active and melts in the range 167° to 172°C. The actual range in which the compound melts is usually less than 2 °C. The first method patented for the synthesis of diphenhydramine was by Rieveschl in 1947, assigned t o Parke, Davis & Co.. The general method involves the reaction of bromodiphenylmethane with the appropriate dialkylamino alcohol in. i n the presence of anhydrous sodium carbonate. The dialkylamino alcohol used is dimethylamino ethanol. This chapter highlights the physical properties, synthesis, stability degradation, metabolic products, and methods of analysis of diphenhydramine hydrochloride.