CALCIFICATION
1955; Elsevier BV; Volume: 212; Issue: 1 Linguagem: Inglês
10.1016/s0021-9258(18)71097-1
ISSN1083-351X
AutoresAlbert E. Sobel, Martin Burger,
ResumoIn previous studies from this laboratory (l-4) it has been shown that vitamin D exerts a marked effect on lead concentrations in the bone and blood of young rats fed a lead-containing diet,.The bone ash of groups fed vitamin D contained a higher percentage of lead regardless of the relation of calcium and phosphorus in the diet.The blood lead was also higher in the animals fed vitamin D. In addition, the influence of Ca:P ratios was manifest,: the higher the Ca: P ratio the higher the level of blood lead.After exposure to lead, rats retain most of the metal in their skeletons, from which it is gradually released into the blood.The present investigation was concerned with the influence of calcium, phosphorus, and vitamin D on lead in the blood and bones of animals which had been transferred from lead-containing to lead-free diets.EXPERIMENTAL Albino rats of similar heredity, raised in this laboratory from an original Wistar strain, were placed at the age of 23 to 25 days on the stock diet of Bills et al. ( 5), to which had been added 0.8 per cent lead as basic lead carbonate.After 29 days on the diet, the animals were divided into three groups and placed on appropriate lead-free diets of the composition indicated in Table I.One-half of each group received daily, in addition, 0.1 CC. of a solution of viosterol in maize oil, administered orally from a pipette (0.1 cc.= 100 i.u. of vitamin
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