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Reversible binding of ethacrynic acid to human serum albumin: Difference circular dichroism study

1999; Wiley; Volume: 11; Issue: 1 Linguagem: Inglês

10.1002/(sici)1520-636x(1999)11

1520-636X

Carlo Bertucci, Barbara Nanni, Piero Salvadori,

Analytical Chemistry and Chromatography

ChiralityVolume 11, Issue 1 p. 33-38 Reversible binding of ethacrynic acid to human serum albumin: Difference circular dichroism study Carlo Bertucci, Carlo Bertucci Centro Studio CNR Macromolecole Stereordinate Otticamente Attive, Dipartimento di Chimica e Chimica Industriale, Università di Pisa, ItalySearch for more papers by this authorBarbara Nanni, Barbara Nanni Centro Studio CNR Macromolecole Stereordinate Otticamente Attive, Dipartimento di Chimica e Chimica Industriale, Università di Pisa, ItalySearch for more papers by this authorPiero Salvadori, Corresponding Author Piero Salvadori Centro Studio CNR Macromolecole Stereordinate Otticamente Attive, Dipartimento di Chimica e Chimica Industriale, Università di Pisa, ItalyDipartimento di Chimica e Chimica Industriale, Università di Pisa, via Risorgimento, 35, 56126, Pisa, ItalySearch for more papers by this author Carlo Bertucci, Carlo Bertucci Centro Studio CNR Macromolecole Stereordinate Otticamente Attive, Dipartimento di Chimica e Chimica Industriale, Università di Pisa, ItalySearch for more papers by this authorBarbara Nanni, Barbara Nanni Centro Studio CNR Macromolecole Stereordinate Otticamente Attive, Dipartimento di Chimica e Chimica Industriale, Università di Pisa, ItalySearch for more papers by this authorPiero Salvadori, Corresponding Author Piero Salvadori Centro Studio CNR Macromolecole Stereordinate Otticamente Attive, Dipartimento di Chimica e Chimica Industriale, Università di Pisa, ItalyDipartimento di Chimica e Chimica Industriale, Università di Pisa, via Risorgimento, 35, 56126, Pisa, ItalySearch for more papers by this author First published: 29 January 1999 https://doi.org/10.1002/(SICI)1520-636X(1999)11:1 3.0.CO;2-UCitations: 17AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract The reversible binding of ethacrynic acid was characterized by a difference circular dichroism method. A 2/1 stoichiometry was determined for the [drug]/[HSA] (human serum albumin) complex. The reversible binding of ethacrynic acid to HSA determines direct competition with ligands that selectivity bind to site II and to the fatty acid site. Furthermore, indirect competition was shown for ligands for site I (anticooperative) and to site III (cooperative). Chirality 11:33–38, 1999. © 1999 Wiley-Liss, Inc. Citing Literature Volume11, Issue11999Pages 33-38 RelatedInformation