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A preliminary report of the HTK randomized multicenter study comparing kidney graft preservation with HTK and EuroCollins solutions

1992; Springer Science+Business Media; Volume: 5; Linguagem: Inglês

10.1111/tri.1992.5.s1.429

1432-2277

Arwin Groenewoud, J. Thorogood,

Organ Transplantation Techniques and Outcomes

Transplant InternationalVolume 5, Issue S1 p. S429-S432 Article A preliminary report of the HTK randomized multicenter study comparing kidney graft preservation with HTK and EuroCollins solutions A. F. Groenewoud, A. F. Groenewoud Department of Surgery, Klinikum Rechts der Isar, München, FRGSearch for more papers by this authorJ. Thorogood, J. Thorogood Eurotransplant, Leiden, The NetherlandsSearch for more papers by this authorfor the HTK Study Group, for the HTK Study GroupSearch for more papers by this author A. F. Groenewoud, A. F. Groenewoud Department of Surgery, Klinikum Rechts der Isar, München, FRGSearch for more papers by this authorJ. Thorogood, J. Thorogood Eurotransplant, Leiden, The NetherlandsSearch for more papers by this authorfor the HTK Study Group, for the HTK Study GroupSearch for more papers by this author First published: January 1992 https://doi.org/10.1111/tri.1992.5.s1.429Citations: 9 A. F. Groenewoud, Department of Surgery, Klinikum Rechts der Isar, Ismaningerstraße 28, 8000 München 80, FRG AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract The main goal of transplantation is to restore good renal function and to improve the quality of life of thousands of dialysis patients, something which can only be achieved by providing them with well functioning grafts. Delayed renal allograft function is a serious problem. It is important to prevent this complication because it makes the diagnosis of acute rejection in the early postoperative period difficult, increases the necessity for diagnostic procedures, introduces dialysis treatments and prolongs hospital stay. The aetiology of delayed graft function (DGF) is multifactorial, and factors including donor management, technique used for organ procurement and preservation, age, anatomical variations in the graft, ischemia periods, use of cyclosporine A (CyA) or recipient immunological reactions have been implicated. Using different preservation solutions DGF rates vary from 30% to 60%. Recent clinical data have demonstrated better preservation and improved renal function posttransplant with HTK and University of Wisconsin (UW) solutions compared to EuroCollins solution. In a randomized multicenter study in collaboration with the Eurotransplant organ exchange organization, the efficacy of the HTK solution in renal transplantation was compared to EuroCollins and UW solutions in two parallel prospective randomized trials. The first preliminary results comparing HTK and EuroCollins solutions are reported here. Citing Literature Volume5, IssueS1January 1992Pages S429-S432 RelatedInformation