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4. IgE, mast cells, basophils, and eosinophils

2003; Elsevier BV; Volume: 111; Issue: 2 Linguagem: Inglês

10.1067/mai.2003.120

1097-6825

Calman Prussin, Dean D. Metcalfe,

Food Allergy and Anaphylaxis Research

IgE, mast cells, basophils, and eosinophils constitute essential elements in allergic inflammation. Allergen-specific IgE, synthesized in response to allergens in the environment and in susceptible individuals, becomes fixed to high-affinity receptors on cellular membranes, especially of mast cells and basophils. If these receptor-bound IgE molecules are aggregated on reexposure to specific allergen, these mast cells and basophils produce mediators that result in the allergic response. Principal among the cells drawn to sites of mediator release is the eosinophil. (J Allergy Clin Immunol 2003;111:S486-94.)