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Helicobacter pylori infection in patients with gastric carcinoma in biopsy and surgical resection specimens

1996; Wiley; Volume: 77; Issue: 6 Linguagem: Inglês

10.1002/(sici)1097-0142(19960315)77

1097-0142

Tomoyuki Shibata, Ichiro Imoto, Yoshio Ohuchi, Yukiko Taguchi, Satoshi Takaji, N. Ikemura, Kazuyuki Nakao, Teruo Shima,

Gastrointestinal disorders and treatments

CancerVolume 77, Issue 6 p. 1044-1049 Original ArticleFree Access Helicobacter pylori infection in patients with gastric carcinoma in biopsy and surgical resection specimens Tomoyuki Shibata M.D., Corresponding Author Tomoyuki Shibata M.D. Third Department of Internal Medicine, Mie University School of Medicine, Mie Prefecture, JapanEdobashi 2-chome, 174 banchi, Tsu-city, Mie Prefecture, 514, Japan===Search for more papers by this authorIchiro Imoto M.D., Ichiro Imoto M.D. Third Department of Internal Medicine, Mie University School of Medicine, Mie Prefecture, JapanSearch for more papers by this authorYoshio Ohuchi M.D., Yoshio Ohuchi M.D. Third Department of Internal Medicine, Mie University School of Medicine, Mie Prefecture, JapanSearch for more papers by this authorYukiko Taguchi M.D., Yukiko Taguchi M.D. Third Department of Internal Medicine, Mie University School of Medicine, Mie Prefecture, JapanSearch for more papers by this authorSatoshi Takaji M.D., Satoshi Takaji M.D. Third Department of Internal Medicine, Mie University School of Medicine, Mie Prefecture, JapanSearch for more papers by this authorNorihisa Ikemura M.D., Norihisa Ikemura M.D. Third Department of Internal Medicine, Mie University School of Medicine, Mie Prefecture, JapanSearch for more papers by this authorKazuyuki Nakao M.D., Kazuyuki Nakao M.D. Third Department of Internal Medicine, Mie University School of Medicine, Mie Prefecture, JapanSearch for more papers by this authorTeruo Shima M.D., Teruo Shima M.D. Third Department of Internal Medicine, Mie University School of Medicine, Mie Prefecture, JapanSearch for more papers by this author Tomoyuki Shibata M.D., Corresponding Author Tomoyuki Shibata M.D. Third Department of Internal Medicine, Mie University School of Medicine, Mie Prefecture, JapanEdobashi 2-chome, 174 banchi, Tsu-city, Mie Prefecture, 514, Japan===Search for more papers by this authorIchiro Imoto M.D., Ichiro Imoto M.D. Third Department of Internal Medicine, Mie University School of Medicine, Mie Prefecture, JapanSearch for more papers by this authorYoshio Ohuchi M.D., Yoshio Ohuchi M.D. Third Department of Internal Medicine, Mie University School of Medicine, Mie Prefecture, JapanSearch for more papers by this authorYukiko Taguchi M.D., Yukiko Taguchi M.D. Third Department of Internal Medicine, Mie University School of Medicine, Mie Prefecture, JapanSearch for more papers by this authorSatoshi Takaji M.D., Satoshi Takaji M.D. Third Department of Internal Medicine, Mie University School of Medicine, Mie Prefecture, JapanSearch for more papers by this authorNorihisa Ikemura M.D., Norihisa Ikemura M.D. Third Department of Internal Medicine, Mie University School of Medicine, Mie Prefecture, JapanSearch for more papers by this authorKazuyuki Nakao M.D., Kazuyuki Nakao M.D. Third Department of Internal Medicine, Mie University School of Medicine, Mie Prefecture, JapanSearch for more papers by this authorTeruo Shima M.D., Teruo Shima M.D. Third Department of Internal Medicine, Mie University School of Medicine, Mie Prefecture, JapanSearch for more papers by this author First published: 15 March 1996 https://doi.org/10.1002/(SICI)1097-0142(19960315)77:6 3.0.CO;2-HCitations: 11AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract BACKGROUND The discrepancy between the high seropositivity for Helicobacter pylori (H. pylori) and the low diagnostic yield of H. pylori organism in gastric biopsies of patients with gastric carcinoma has yet to be clarified. The present study attempted to clarify this controversial point by performing a comparative evaluation between the detection rate of H. pylori in biopsy and in surgical specimens. METHODS The presence of H. pylori in biopsy samples from 50 patients with gastric carcinoma and 50 age-matched controls was evaluated histologically. Six histologic sections were obtained from gastric noncancerous areas and the presence of H. pylori was evaluated in those H. pylori negative patients who underwent gastrectomy. RESULTS H. pylori was positive in 35 of 50 controls (70%). In biopsy samples, H. pylori was detected in 29 of 37 patients (78.4%) with early gastric carcinoma, 7 of 13 (53.8%) with advanced carcinoma, 16 of 23 (69.6%) with intestinal type of gastric carcinoma, and 20 of 27 (74.1%) with diffuse type of carcinoma. Studies carried out in gastrectomy specimens increased the diagnostic yield of H. pylori to 33 (89.2%), 12 (92.3%), 19 (82.6%), and 26 (96.3%) in patients with early, advanced, intestinal, and diffuse types of gastric carcinoma, respectively. Overall, H. pylori was positive in 36 biopsy specimens (72%) and 45 gastrectomy specimens (90%). Namely, the detection of H. pylori infection was significantly higher in patients with gastric carcinoma using gastrectomy specimens than in patients with gastric carcinoma using biopsy specimens only (P < 0.05). CONCLUSIONS These results indicate that the actual prevalence of H. pylori in patients with gastric carcinoma is considerably higher than that previously reported. Cancer 1996;77:1044-9. Citing Literature Volume77, Issue615 March 1996Pages 1044-1049 ReferencesRelatedInformation