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Parental cigarette smoking and risk for congenital anomalies of the heart, neural tube, or limb

1996; Wiley; Volume: 53; Issue: 4 Linguagem: Inglês

10.1002/(sici)1096-9926(199604)53

2472-1727

Cathy R. Wasserman, Gary M. Shaw, Cynthia D. O’Malley, M Tolarová, Edward J. Lammer,

Cleft Lip and Palate Research

TeratologyVolume 53, Issue 4 p. 261-267 Original Article Parental cigarette smoking and risk for congenital anomalies of the heart, neural tube, or limb Cathy R. Wasserman, Corresponding Author Cathy R. Wasserman March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Emeryville, California 94608California Birth Defects Monitoring Program, 1900 Powell St., Suite 1050, Emeryville, CA 94608Search for more papers by this authorGary M. Shaw, Gary M. Shaw March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Emeryville, California 94608Search for more papers by this authorCynthia D. O'Malley, Cynthia D. O'Malley March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Emeryville, California 94608Search for more papers by this authorMarie M. Tolarova, Marie M. Tolarova March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Emeryville, California 94608Search for more papers by this authorEdward J. Lammer, Edward J. Lammer Department of Medical Genetics, Children's Hospital, Oakland, California 94609Search for more papers by this author Cathy R. Wasserman, Corresponding Author Cathy R. Wasserman March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Emeryville, California 94608California Birth Defects Monitoring Program, 1900 Powell St., Suite 1050, Emeryville, CA 94608Search for more papers by this authorGary M. Shaw, Gary M. Shaw March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Emeryville, California 94608Search for more papers by this authorCynthia D. O'Malley, Cynthia D. O'Malley March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Emeryville, California 94608Search for more papers by this authorMarie M. Tolarova, Marie M. Tolarova March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Emeryville, California 94608Search for more papers by this authorEdward J. Lammer, Edward J. Lammer Department of Medical Genetics, Children's Hospital, Oakland, California 94609Search for more papers by this author First published: April 1996 https://doi.org/10.1002/(SICI)1096-9926(199604)53:4 3.0.CO;2-5Citations: 111AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Risks for selected congenital anomalies from parental smoking were investigated in a case-control study in California. Mothers of 207 infants with conotruncal heart defects, 264 infants with neural tube defects, 178 infants with limb deficiencies, and 481 live born control infants delivered in 1987–1988 were interviewed by telephone. Modestly elevated risks were observed for conotruncal heart defects and limb deficiencies, associated primarily with both parents smoking. An odds ratio of 1.9 (95 percent confidence interval 1.2–3.1) was observed for conotruncal heart defects and an odds ratio of 1.7 (95% confidence interval 0.96–2.9) for limb deficiencies when both parents smoked compared to neither parent smoking. We did not observe increased risks associated with maternal smoking in the absence of paternal smoking, although an increased risk associated with paternal smoking in the absence of maternal smoking was observed for limb deficiencies in offspring. For conotruncal defects, the risks associated with parental smoking differed among race/ethnic groups. Parental smoking was not associated with increased risks for neural tube defects. Observed risks did not change substantially when adjusted for maternal vitamin use, alcohol use, and gravidity. Some heterogeneity in risk was observed for phenotypic case subgroups, but data were too sparse to draw firm inferences. © 1996 Wiley-Liss, Inc. Citing Literature Volume53, Issue4April 1996Pages 261-267 RelatedInformation