Dose-Ranging Study in Younger Adult and Elderly Patients of ORG 9487, a New, Rapid-Onset, Short-Duration Muscle Relaxant
1997; Lippincott Williams & Wilkins; Volume: 84; Issue: 5 Linguagem: Inglês
10.1213/00000539-199705000-00011
ISSN1526-7598
AutoresRaymond Kahwaji, David R. Bevan, George B. Bikhazi, C. A. Shanks, Robert J. Fragen, John B. Dyck, Martin S. Angst, Richard S. Matteo,
Tópico(s)Anesthesia and Neurotoxicity Research
ResumoThe purpose of this multicenter, randomized, assessor-blind placebo-controlled study was to determine which of five doses of the new, rapid-onset neuromuscular relaxant, ORG 9487, provided both good to excellent tracheal intubating conditions 60 s after administration and a clinical duration of action or=to 0.7) were measured. Dose-dependent changes were observed in tracheal intubating conditions and neuromuscular block. Good to excellent intubating conditions at 60 s were present in most younger adult (52 of 60) and elderly (26 of 31) patients administered doses >or=to1.5 mg/kg. Mean clinical durations <20 min were observed in adult patients at doses up to 2.0 mg/kg and in geriatric patients up to 1.5 mg/kg. Thus, doses of 1.5-2.0 mg/kg ORG 9487 enabled both rapid tracheal intubation and a short clinical duration of action in adult and elderly patients. (Anesth Analg 1997;84:1011-8)
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