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Top‐Down Chemoenzymatic Approach to a High‐Mannose‐Type Glycan Library: Synthesis of a Common Precursor and Its Enzymatic Trimming

2013; Wiley; Volume: 125; Issue: 29 Linguagem: Inglês

10.1002/ange.201301613

1521-3757

Akihiko Koizumi, Ichiro Matsuo, Maki Takatani, Akira Seko, Masakazu Hachisu, Yoichi Takeda, Yukishige Ito,

Polyamine Metabolism and Applications

Angewandte ChemieVolume 125, Issue 29 p. 7574-7579 Zuschrift Top-Down Chemoenzymatic Approach to a High-Mannose-Type Glycan Library: Synthesis of a Common Precursor and Its Enzymatic Trimming† Dr. Akihiko Koizumi, Dr. Akihiko Koizumi ERATO, Ito Glycotrilogy Project (Japan) Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)Search for more papers by this authorProf. Ichiro Matsuo, Prof. Ichiro Matsuo Department of Chemistry and Chemical Biology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515 (Japan)Search for more papers by this authorMaki Takatani, Maki Takatani ERATO, Ito Glycotrilogy Project (Japan) Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)Search for more papers by this authorDr. Akira Seko, Dr. Akira Seko ERATO, Ito Glycotrilogy Project (Japan) Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)Search for more papers by this authorDr. Masakazu Hachisu, Dr. Masakazu Hachisu ERATO, Ito Glycotrilogy Project (Japan) Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)Search for more papers by this authorDr. Yoichi Takeda, Corresponding Author Dr. Yoichi Takeda yotakeda@riken.jp ERATO, Ito Glycotrilogy Project (Japan) Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)ERATO, Ito Glycotrilogy Project (Japan) Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)Search for more papers by this authorDr. Yukishige Ito, Corresponding Author Dr. Yukishige Ito yukito@riken.jp ERATO, Ito Glycotrilogy Project (Japan) Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan) Synthetic Cellular Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)ERATO, Ito Glycotrilogy Project (Japan) Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)Search for more papers by this author Dr. Akihiko Koizumi, Dr. Akihiko Koizumi ERATO, Ito Glycotrilogy Project (Japan) Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)Search for more papers by this authorProf. Ichiro Matsuo, Prof. Ichiro Matsuo Department of Chemistry and Chemical Biology, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515 (Japan)Search for more papers by this authorMaki Takatani, Maki Takatani ERATO, Ito Glycotrilogy Project (Japan) Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)Search for more papers by this authorDr. Akira Seko, Dr. Akira Seko ERATO, Ito Glycotrilogy Project (Japan) Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)Search for more papers by this authorDr. Masakazu Hachisu, Dr. Masakazu Hachisu ERATO, Ito Glycotrilogy Project (Japan) Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)Search for more papers by this authorDr. Yoichi Takeda, Corresponding Author Dr. Yoichi Takeda yotakeda@riken.jp ERATO, Ito Glycotrilogy Project (Japan) Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)ERATO, Ito Glycotrilogy Project (Japan) Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)Search for more papers by this authorDr. Yukishige Ito, Corresponding Author Dr. Yukishige Ito yukito@riken.jp ERATO, Ito Glycotrilogy Project (Japan) Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan) Synthetic Cellular Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)ERATO, Ito Glycotrilogy Project (Japan) Science and Technology Agency, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)Search for more papers by this author First published: 06 June 2013 https://doi.org/10.1002/ange.201301613Citations: 12 † We thank Dr. Akihiro Ishiwata for his valuable advice as wells as Akemi Takahashi and Satoko Shirahata for their technical assistance. We are also grateful to Dr. Yoshio Sakaguchi and his staff of the Materials Characterization Team in RIKEN Advanced Support Division for elemental analyses. Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Es zählt, was übrig bleibt: Eine Methode zur Erstellung einer Bibliothek mannosereicher Glycane durch systematischen enzymatischen Zuschnitt einer einzigen synthetischen Vorstufe mit Man9-Gerüst wurde entwickelt. Die effiziente chemische Synthese dieser gemeinsamen Tetradecasaccharid-Vorstufe und der orthogonale enzymatische Zuschnitt unter Erhalt aller M8-9- und G1M8-9-Derivate werden vorgestellt. G=Glucose, M=Mannose. Citing Literature Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description ange_201301613_sm_miscellaneous_information.pdf8.1 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume125, Issue29July 15, 2013Pages 7574-7579 This is the German version of Angewandte Chemie. Note for articles published since 1962: Do not cite this version alone. Take me to the International Edition version with citable page numbers, DOI, and citation export. We apologize for the inconvenience. RelatedInformation