Superinfection and the evolution of parasite virulence
1994; Royal Society; Volume: 255; Issue: 1342 Linguagem: Inglês
10.1098/rspb.1994.0012
ISSN1471-2954
AutoresMartin A. Nowak, Robert M. May,
Tópico(s)Evolutionary Game Theory and Cooperation
ResumoRestricted accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Nowak Martin A. and May Robert Mccredie 1994Superinfection and the evolution of parasite virulenceProc. R. Soc. Lond. B.25581–89http://doi.org/10.1098/rspb.1994.0012SectionRestricted accessArticleSuperinfection and the evolution of parasite virulence Martin A. Nowak Google Scholar Find this author on PubMed Search for more papers by this author and Robert Mccredie May Google Scholar Find this author on PubMed Search for more papers by this author Martin A. Nowak Google Scholar Find this author on PubMed and Robert Mccredie May Google Scholar Find this author on PubMed Published:22 January 1994https://doi.org/10.1098/rspb.1994.0012AbstractEarlier ideas that parasites evolve toward becoming harmless to their hosts have, in recent years, given way to more analytic studies, focused on the 'basic reproductive rate', Ro, of individual parasites. In general, the biology of the parasite life cycle will lead to constraining relations between virulence (parasite-associated host death or reduction in fertility) and transmissibility: the maximum Ro may then be attained by virulence being high, or low, or at some intermediate level, depending on the details of the constraining relations. Such studies have not generally included superinfection (where an already-infected host is infected by another parasite). Here we propose a general, but simple, model of superinfection, which is amenable to analytical treatment. In such models selection does not simply act to maximize Ro; superinfection leads to selection for higher levels of virulence, highly polymorphic parasite populations and very complicated dynamics. We calculate the equilibrium distribution of parasite strains and the maximum level of virulence that can be maintained by superinfection. We also note the equivalence between our 'superinfection model' and recent approaches to the study of the meta-population dynamics of multispecies interactions.FootnotesThis text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR. 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