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Synthetic Substrates for an Endoplasmic Reticulum Protein‐Folding Sensor, UDP‐Glucose: Glycoprotein Glucosyltransferase

2005; Wiley; Volume: 117; Issue: 48 Linguagem: Inglês

10.1002/ange.200502723

1521-3757

Kiichiro Totani, Yoshito Ihara, Ichiro Matsuo, Hiroyuki Koshino, Yukishige Ito,

Galectins and Cancer Biology

Angewandte ChemieVolume 117, Issue 48 p. 8164-8168 Zuschrift Synthetic Substrates for an Endoplasmic Reticulum Protein-Folding Sensor, UDP-Glucose: Glycoprotein Glucosyltransferase† Kiichiro Totani Dr., Kiichiro Totani Dr. RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan CREST, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-1102, Japan, Fax: (+81) 48-482-4680Search for more papers by this authorYoshito Ihara Dr., Yoshito Ihara Dr. Department of Biochemistry & Molecular Biology of Disease, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, JapanSearch for more papers by this authorIchiro Matsuo Dr., Ichiro Matsuo Dr. RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan CREST, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-1102, Japan, Fax: (+81) 48-482-4680Search for more papers by this authorHiroyuki Koshino Dr., Hiroyuki Koshino Dr. RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama 351-0198, JapanSearch for more papers by this authorYukishige Ito Dr., Yukishige Ito Dr. yukito@riken.jp RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan CREST, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-1102, Japan, Fax: (+81) 48-482-4680Search for more papers by this author Kiichiro Totani Dr., Kiichiro Totani Dr. RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan CREST, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-1102, Japan, Fax: (+81) 48-482-4680Search for more papers by this authorYoshito Ihara Dr., Yoshito Ihara Dr. Department of Biochemistry & Molecular Biology of Disease, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, JapanSearch for more papers by this authorIchiro Matsuo Dr., Ichiro Matsuo Dr. RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan CREST, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-1102, Japan, Fax: (+81) 48-482-4680Search for more papers by this authorHiroyuki Koshino Dr., Hiroyuki Koshino Dr. RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama 351-0198, JapanSearch for more papers by this authorYukishige Ito Dr., Yukishige Ito Dr. yukito@riken.jp RIKEN (The Institute of Physical and Chemical Research), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan CREST, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-1102, Japan, Fax: (+81) 48-482-4680Search for more papers by this author First published: 08 December 2005 https://doi.org/10.1002/ange.200502723Citations: 12 † This work was supported by the special postdoctoral researchers program at RIKEN. We thank A. Takahashi for technical assistance. Financial support from the Presidential Fund of RIKEN and the Ministry of Education, Culture, Sports, Science, and Technology (Grant-in-Aid for Young Scientists (B) No. 17750170 and Grant-in-Aid for Creative Scientific Research No. 17GS0420) is acknowledged. UDP=uridine 5′-diphosphate. Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract In der Qualitätskontrolle von Glycoproteinen fungiert UDP-Glucose:Glycoprotein-Glucosyltransferase (UGGT) als Faltungssensor. Es glucosyliert Man9GlcNAc2 falsch gefalteter Glycoproteine zu Glc1Man9GlcNAc2, das ein Ligand von Calnexin und Calreticulin ist. Das synthetische Substrat Man9GlcNAc2-MTX kann zur quantitativen Analyse von UGGT verwendet werden. UDP=Uridin-5′-diphosphat, Glc=D-Glucose, Man= D-Mannose, GlcNAc=N-Acetyl- D-glucosamin, MTX=Methotrexat. Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2005/z502723_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume117, Issue48December 9, 2005Pages 8164-8168 This is the German version of Angewandte Chemie. Note for articles published since 1962: Do not cite this version alone. 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