The peristaltic reflex induced by mucosal stimuli in human and guinea pig intestine is mediated by distinct mucosal 5-HT receptors
1995; Elsevier BV; Volume: 108; Issue: 4 Linguagem: Inglês
10.1016/0016-5085(95)26712-3
ISSN1528-0012
AutoresSpecificity Ford, Alan R. Zinsmeister, R Hanson, M Camiueri,
Tópico(s)Music Therapy and Health
ResumoExcessive colonic sensitivity to distension may reflect altered peripheral or central perception of afferent signals.Our hypothesis was that psychoseasory arousal increases perception of stimuli in different regions of the human colon.Our aim was to determine the perception of "gas" and "pain" in the transverse and sigmoid (TC, SC) colon of healthy volunteers under different arousal conditions.Methods: A double barostat balloon assembly was positioned into the cleansed colon of 22 healthy subjects.Colon distensions (2-rain duration, separated by 2 rain) were performed in random order for site (TC, SC) and inflation pressure (8, 16, and 32 mmHg above operating pressure).Effects of distensions were studied twice: once before, and once during the tes t period when subjects were randomized to sham (listening to "Hitchhiker's Guide to the Galaxy"), arousal (dichotomous listening), or progressive muscular relaxation.Gas and pain were assessed byl00 mm visual analog scores during each distension.Indices of depression (H.A.D. Inventory) and threshold for induction of hand pain and maximal tolerated time during cold stress were covariates in the model.A.n.....alysis: We compared changes (pre vs. during test) in gas and pain scores among the treatment groups using multivariate ANCOVA..R.esults: Arousal significantly increased sensation of gas (p<0.01),not pain (p=ns), during distension of TC but not SC.This effect was most marked with stimulation at 16 mmHg, and was similar but not significant for 8 mmHg and 32 mmHg stimulus.The covariates (depression score, somatic sensitivity)were not significantly associated with the sensory scores.Data show mean ± SE; p<0.01.
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