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A Genetically Encoded Photocaged Tyrosine

2006; Wiley; Volume: 118; Issue: 17 Linguagem: Inglês

10.1002/ange.200600264

1521-3757

Alexander Deiters, Dan Groff, Youngha Ryu, Jianming Xie, Peter G. Schultz,

CRISPR and Genetic Engineering

Angewandte ChemieVolume 118, Issue 17 p. 2794-2797 Zuschrift A Genetically Encoded Photocaged Tyrosine† Alexander Deiters Prof., Alexander Deiters Prof. Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USA These authors contributed equally.Search for more papers by this authorDan Groff, Dan Groff Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+1) 858-784-9440 These authors contributed equally.Search for more papers by this authorYoungha Ryu Dr., Youngha Ryu Dr. Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+1) 858-784-9440Search for more papers by this authorJianming Xie, Jianming Xie Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+1) 858-784-9440Search for more papers by this authorPeter G. Schultz Prof., Peter G. Schultz Prof. schultz@scripps.edu Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+1) 858-784-9440Search for more papers by this author Alexander Deiters Prof., Alexander Deiters Prof. Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USA These authors contributed equally.Search for more papers by this authorDan Groff, Dan Groff Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+1) 858-784-9440 These authors contributed equally.Search for more papers by this authorYoungha Ryu Dr., Youngha Ryu Dr. Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+1) 858-784-9440Search for more papers by this authorJianming Xie, Jianming Xie Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+1) 858-784-9440Search for more papers by this authorPeter G. Schultz Prof., Peter G. Schultz Prof. schultz@scripps.edu Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA, Fax: (+1) 858-784-9440Search for more papers by this author First published: 11 April 2006 https://doi.org/10.1002/ange.200600264Citations: 57 † A.D. gratefully acknowledges a postdoctoral fellowship from the Deutsche Forschungsgemeinschaft. This work was supported by funding from the National Institutes of Health (GM62159) and the Department of Energy (ER46051). This is manuscript 17952-CH of The Scripps Research Institute. Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Proteinaktivierung mit Licht: Ein photoaktivierbarer Tyrosinrest wurde in E. coli als Antwort auf das Amber-Codon, TAG, genetisch codiert. Nach Substitution am Tyr 503 im aktiven Zentrum der β-Galactosidase kann das Enzym in vitro oder direkt im Bakterium mit 360-nm-Licht photoaktiviert werden. Die Methode könnte zur Photoregulierung biologischer Prozesse wie Transkription, Signaltransduktion und Zell-Trafficking führen. Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2006/z600264_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume118, Issue17April 21, 2006Pages 2794-2797 This is the German version of Angewandte Chemie. Note for articles published since 1962: Do not cite this version alone. Take me to the International Edition version with citable page numbers, DOI, and citation export. We apologize for the inconvenience. RelatedInformation