TMC-207
2008; Elsevier BV; Volume: 88; Issue: 2 Linguagem: Inglês
10.1016/s1472-9792(08)70029-5
ISSN1873-281X
Tópico(s)Pneumocystis jirovecii pneumonia detection and treatment
ResumoGeneric and additional names: TMC-207; also known as R207910CAS name: 1-(6-bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-naphthalen-1-yl-1-phenyl-butan-2-olCAS registry #: 654653-93-7Molecular formula: C32H31BrN2O2Molecular weight: 555.51Intellectual property rights: Johnson & Johnson has obtained patents for this compound. Its subsidiary, Tibotec, is currently managing human clinical trials of this compound.Derivatives: 20 molecules in series have an MIC below 0.5 μg/mlFormulation and optimal human dosage: Reasonable bioavailability was found with oral solutions. Solid formulations are under development. Oral administration achieved high in vivo activity.Download : Download high-res image (24KB)Download : Download full-size image
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