Mild and Efficient H/D Exchange of Alkanes Based on CH Activation Catalyzed by Rhodium on Charcoal
2008; Wiley; Volume: 120; Issue: 29 Linguagem: Inglês
10.1002/ange.200800941
ISSN1521-3757
AutoresTomohiro Maegawa, Yuta Fujiwara, Yuya Inagaki, Hiroyoshi Esaki, Yasunari Monguchi, Hironao Sajiki,
Tópico(s)Amino Acid Enzymes and Metabolism
ResumoAngewandte ChemieVolume 120, Issue 29 p. 5474-5477 Zuschrift Mild and Efficient H/D Exchange of Alkanes Based on CH Activation Catalyzed by Rhodium on Charcoal† Tomohiro Maegawa Dr., Tomohiro Maegawa Dr. Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi Gifu 502-8585 (Japan), Fax: (+81) 58-237-5979 http://www.gifu-pu.ac.jp/lab/yakuhin/index.htmlSearch for more papers by this authorYuta Fujiwara, Yuta Fujiwara Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi Gifu 502-8585 (Japan), Fax: (+81) 58-237-5979 http://www.gifu-pu.ac.jp/lab/yakuhin/index.htmlSearch for more papers by this authorYuya Inagaki, Yuya Inagaki Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi Gifu 502-8585 (Japan), Fax: (+81) 58-237-5979 http://www.gifu-pu.ac.jp/lab/yakuhin/index.htmlSearch for more papers by this authorHiroyoshi Esaki Dr., Hiroyoshi Esaki Dr. Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi Gifu 502-8585 (Japan), Fax: (+81) 58-237-5979 http://www.gifu-pu.ac.jp/lab/yakuhin/index.htmlSearch for more papers by this authorYasunari Monguchi Dr., Yasunari Monguchi Dr. Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi Gifu 502-8585 (Japan), Fax: (+81) 58-237-5979 http://www.gifu-pu.ac.jp/lab/yakuhin/index.htmlSearch for more papers by this authorHironao Sajiki Prof. Dr., Hironao Sajiki Prof. Dr. [email protected] Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi Gifu 502-8585 (Japan), Fax: (+81) 58-237-5979 http://www.gifu-pu.ac.jp/lab/yakuhin/index.htmlSearch for more papers by this author Tomohiro Maegawa Dr., Tomohiro Maegawa Dr. Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi Gifu 502-8585 (Japan), Fax: (+81) 58-237-5979 http://www.gifu-pu.ac.jp/lab/yakuhin/index.htmlSearch for more papers by this authorYuta Fujiwara, Yuta Fujiwara Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi Gifu 502-8585 (Japan), Fax: (+81) 58-237-5979 http://www.gifu-pu.ac.jp/lab/yakuhin/index.htmlSearch for more papers by this authorYuya Inagaki, Yuya Inagaki Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi Gifu 502-8585 (Japan), Fax: (+81) 58-237-5979 http://www.gifu-pu.ac.jp/lab/yakuhin/index.htmlSearch for more papers by this authorHiroyoshi Esaki Dr., Hiroyoshi Esaki Dr. Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi Gifu 502-8585 (Japan), Fax: (+81) 58-237-5979 http://www.gifu-pu.ac.jp/lab/yakuhin/index.htmlSearch for more papers by this authorYasunari Monguchi Dr., Yasunari Monguchi Dr. Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi Gifu 502-8585 (Japan), Fax: (+81) 58-237-5979 http://www.gifu-pu.ac.jp/lab/yakuhin/index.htmlSearch for more papers by this authorHironao Sajiki Prof. Dr., Hironao Sajiki Prof. Dr. [email protected] Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi Gifu 502-8585 (Japan), Fax: (+81) 58-237-5979 http://www.gifu-pu.ac.jp/lab/yakuhin/index.htmlSearch for more papers by this author First published: 03 July 2008 https://doi.org/10.1002/ange.200800941Citations: 22 † We are grateful to N.E. Chemcat for providing catalysts. Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Ganz einfach gelingt der H/D-Austausch nichtfunktionalisierter Alkane in Gegenwart von Rh/C in D2O unter H2 bei 160 °C (siehe Schema). Mit billigen Reagentien und unter milden Reaktionsbedingungen können – nach einer einfachen Aufarbeitung – vollständig deuterierte Produkte erhalten werden. 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