Hepatitis C
1998; Elsevier BV; Volume: 351; Issue: 9099 Linguagem: Inglês
10.1016/s0140-6736(97)07361-3
ISSN1474-547X
Autores Tópico(s)Liver Disease Diagnosis and Treatment
ResumoIn the last decade hepatitis C has emerged from obscurity as a disease (non A, non B hepatitis) familiar to only a few experts, to being recognised as a major public health problem worldwide, responsible for chronic liver disease and a variety of extra-hepatic manifestations. The breakthrough responsible for this emergence came in 1989 when the hepatitis C virus (HCV) was discovered 1 Choo Q-L Kuo G Weiner AJ et al. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science. 1989; 244: 359-362 Crossref PubMed Scopus (6286) Google Scholar with modern techniques of molecular cloning. Subsequently, a variety of reliable diagnostic assays were developed, allowing detailed study of the epidemiology and disease associations of HCV. This article can be found in the following collections:The Lancet Seminars
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