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Transgenic Mice Carrying the Mouse Mammary Tumor Virus ras Fusion Gene: Distinct Effects in Various Tissues

1989; Taylor & Francis; Volume: 9; Issue: 2 Linguagem: Inglês

10.1128/mcb.9.2.854-859.1989

1098-5549

Patrick Tremblay, F. Pothier, Trang Hoang, Gilles Tremblay, Seymour Brownstein, Allan Liszauer, Paul Jolicoeur,

Cancer Research and Treatments

Transgenic mice carrying the v-Ha-ras oncogene under the control of the mouse mammary tumor virus long terminal repeat were produced. These mice exhibit several phenotypes: mammary tumors, bilateral hyperplasia of the harderian lacrimal gland, primary bronchio-alveolar lung adenocarcinoma, and splenomegaly. High levels of the transgene RNA were detected in mammary, harderian, and lung tumors. Accumulation of cells of the myeloid lineages was found in enlarged spleens. This phenotype may represent an indirect effect of v-Ha-ras expression on myeloid progenitors. Our data illustrate the cell-specific effects of v-Ha-ras.