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Cortisol Transport and Disappearance

1964; American College of Physicians; Volume: 60; Issue: 4 Linguagem: Inglês

10.7326/0003-4819-60-4-641

1539-3704

W. R. Beisel, Vincent C. DiRaimondo, Peter H. Forsham,

Electrolyte and hormonal disorders

Article1 April 1964Cortisol Transport and DisappearanceW. R. BEISEL, M.D., V. C. DIRAIMONDO, M.D., P. H. FORSHAM, M.D.W. R. BEISEL, M.D.Search for more papers by this author, V. C. DIRAIMONDO, M.D.Search for more papers by this author, P. H. FORSHAM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-641 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptReversible binding by plasma proteins appears fundamental in regulating the availability of circulating cortisol*for physiologic activity in tissues, for inactivation by the liver, or for excretion by the kidneys. Two plasma protein components are involved in binding nonmetabolized cortisol (1-3). At physiologic concentrations, plasma cortisol is bound predominantly by an alpha globulin termed corticosteroid-binding globulin (CBG) (1) or transcortin (3). This protein has a high binding affinity for cortisol, but is present only in low concentrations and so becomes rapidly saturated as the level of plasma cortisol is raised above normal. The other binding protein, plasma albumin...References1. DAUGHADAY WH: Binding of corticosteroids by plasma proteins. III. The binding of corticosteroid and related hormones by human plasma and plasma protein fractions as measured by equilibrium dialysis. J. Clin. Invest. 37: 511, 1958. CrossrefMedlineGoogle Scholar2. UPTONBONDY GVPK: The binding of cortisol by plasma protein. Arch. Biochem. 78: 197, 1958. CrossrefMedlineGoogle Scholar3. SLAUNWHITESANDBERG WRAA: Transcortin: a corticosteroid-binding protein of plasma. J. Clin. Invest. 38: 384, 1959. CrossrefMedlineGoogle Scholar4. BEISELDIRAIMONDOCHAOROSNERFORSHAM WRVCPYJPH: The influence of plasma protein binding on the extra-adrenal metabolism of cortisol in normal, hyperthyroid, and hypothyroid subjects. Submitted to Metabolism. Google Scholar5. MILLS IH: Transport and metabolism of steroids. Brit. Med. Bull. 127-133, 1962. CrossrefMedlineGoogle Scholar6. YATESURQUHART FEJ: Control of plasma concentrations of adrenocortical hormones. Physiol. Rev. 42: 359, 1962. CrossrefMedlineGoogle Scholar7. SANDBERGSLAUNWHITE AAWR: Transcortin: a corticosteroid-binding protein of plasma. V. In vitro inhibition of cortisol metabolism. J. Clin. Invest. 42: 51, 1963. CrossrefMedlineGoogle Scholar8. SLAUNWHITELOCKIEBACKSANDBERG WRGNNAA: Inactivity in vivo of transcortin-bound cortisol. Science 135: 1062, 1962. CrossrefMedlineGoogle Scholar9. PETERSONWYNGAARDENGUERRABRODIEBUNIM REJBSIBBJJ: The physiological disposition and metabolic fate of hydrocortisone in man. J. Clin. Invest. 34: 1779, 1955. CrossrefMedlineGoogle Scholar10. MIGEONLAWRENCEBERTRANDHOLMAN CJBJGH: In vivo distribution of some 17-hydroxy-corticosteroids between the plasma and red blood cells of man. J. Clin. Endocr. 19: 1411, 1959. CrossrefGoogle Scholar11. FARESEPLAGER RVJF: The in vitro red blood cell uptake of C14-cortisol: studies of plasma protein binding of cortisol in normal and abnormal states. J. Clin. Invest. 41: 53, 1962. CrossrefMedlineGoogle Scholar12. VERMEULEN A: Role of the erythrocytes in transport and metabolism of 4-14C-cortisol. Acta Endocr. (København) 37: 348, 1961. MedlineGoogle Scholar13. KETCHEL MM: Physiological and radio-isotopic evidence for the binding of hydrocortisone by human leucocytes in vitro. Endocrinology 69: 60, 1961. CrossrefMedlineGoogle Scholar14. WESTPHALASHLEYSELDEN UBDGL: Steroid-protein interactions. VII. Interactions of progesterone and corticosteroids with human plasma proteins determined by multiple equilibrium dialysis. Report No. 444, U. S. Army Medical Research Laboratory, Fort Knox, Kentucky, October, 1960. Google Scholar15. DEVENUTOKELLEHERWESTPHAL FPCU: Interactions between corticosteroids and fractions of rat liver and muscle cells as determined by "equilibrium fractionation" and equilibrium dialysis. Report No. 537, U. S. Army Medical Research Laboratory, Fort Knox, Kentucky, April 1962. Google Scholar16. DAUGHADAY WH: Binding of corticosteroids by plasma. IV. The electrophoretic demonstration of corticosteroid binding globulin. J. Clin. Invest. 37: 519, 1958. CrossrefMedlineGoogle Scholar17. SEALDOE USRP: Purification and properties of "transcortin," the corticosteroid-binding globulin. Fed. Proc. 20: 179, 1961. Google Scholar18. DAUGHADAY WH: Binding of corticosteroids by plasma proteins. I. Dialysis equilibrium and renal clearance studies. J. Clin. Invest. 35: 1428, 1956. CrossrefMedlineGoogle Scholar19. MEYERLAYNETAITPINCUS CJDSJFG: The binding of aldosterone to plasma proteins in normal, pregnant, and steroid-treated women. J. Clin. Invest. 40: 1663, 1961. CrossrefMedlineGoogle Scholar20. MILLSSCHEDLCHENBARTTER IHHPPSFC: The effect of estrogen administration on the metabolism and protein binding of hydrocortisone. J. Clin. Endocr. 20: 515, 1960. CrossrefMedlineGoogle Scholar21. CHENMILLSBARTTER PSIHFC: Ultrafiltration studies of steroid-protein binding. J. Endocr. 23: 129, 1961. CrossrefMedlineGoogle Scholar22. WESTPHAL U: Interaction between hydrocortisone-4-C14 or progesterone-4-C14 and serum albumin as demonstrated by ultracentrifugation and electrophoresis. Endocrinology 57: 456, 1955. CrossrefMedlineGoogle Scholar23. DE MOORHEIRWEGHHEREMANSDECLERCK-RASKIN PKJFM: Protein Binding of Corticoids Studied by Gel Filtration. J. Clin Invest. 41: 816, 1962. CrossrefMedlineGoogle Scholar24. DAUGHADAYMARIZ WHIK: Corticosteroid-binding globulin: Its properties and quantitation. Metabolism 10: 936, 1961. Google Scholar25. BOOTHDIXONGRAYGREENAWAYHOLNESS MPFCHJMNJ: Protein binding of cortisol in health and in pregnancy. J. Endocr. 23: 25, 1961. CrossrefMedlineGoogle Scholar26. WARRENSALHANICK JCHA: Measurement of cortical binding capacity in human plasma. Proc. Soc. Exp. Biol. Med. 105: 624, 1960. CrossrefMedlineGoogle Scholar27. DAUGHADAYADLERMARIZRASINSKI WHREIKDC: Measurement of the binding capacity of corticosteroid-binding globulin in human plasma. J. Clin. Endocr. 22: 704, 1962. CrossrefGoogle Scholar28. SANDBERGSLAUNWHITE AAWR: Transcortin: a corticosteroid-binding protein of plasma. II. Levels in various conditions and the effects of estrogens. J. Clin. Invest. 38: 1290, 1959. CrossrefMedlineGoogle Scholar29. PETERSONNOKESCHENBLACK REGPSRL: Estrogens and adrenocortical function in man. J. Clin. Endocr. 20: 495, 1960. CrossrefGoogle Scholar30. DAUGHADAY WH: Binding of corticosteroids by plasma proteins. V. Corticosteroid-binding globulin activity in normal human beings and in certain disease states. Arch. Intern. Med. (Chicago) 101: 286, 1958. CrossrefGoogle Scholar31. EIK-NESSCHELLMANLUMRYSAMUELS KJARLT: The binding of steroids to protein. I. Solubility determinations. J. Biol. Chem. 206: 411, 1954. CrossrefMedlineGoogle Scholar32. SANDBERGSLAUNWHITECARTER AAWRAC: Transcortin: a corticosteroid-binding protein of plasma. III. The effects of various steroids. J. Clin. Invest. 39: 1914, 1960. CrossrefMedlineGoogle Scholar33. FLORINIBUYSKE JRDA: Plasma protein binding of triamcinolone-H3 and hydrocortisone-4-C14. J. Biol. Chem. 236: 247, 1961. CrossrefMedlineGoogle Scholar34. DAUGHADAYHOLLOSZYMARIZ WHJIK: Binding of corticosteroids by plasma proteins. VI. The binding of cortisol and aldosterone by corticosteroid-binding globulin and by the estrogen-induced binding system of plasma. J. Clin. Endocr. 21: 53, 1961. CrossrefGoogle Scholar35. DAVIDSONDEVENUTOWESTPHAL ETFU: Steroid-protein interactions. IX. The interaction of aldosterone with human serum proteins in competition with spirolactones and other steroids. Report No. 541, U. S. Army Medical Research Laboratory, Fort Knox, Kentucky, June, 1962. Google Scholar36. TANAKASTARR SP: A euthyroid man without thyroxine-binding globulin. A letter to the editor, J. Clin. Endocr. 19: 485, 1959. CrossrefGoogle Scholar37. INGBAR SH: Clinical and physiological observations in a patient with an idiopathic decrease in the thyroxine-binding globulin of plasma. J. Clin. Invest. 40: 2053, 1961. CrossrefMedlineGoogle Scholar38. BEISELZAINALHANEDIRAIMONDOFORSHAM WRHSVCPH: Low thyroidal iodine uptake with euthyroidism associated with deficient thyroid-binding globulin but normal cortisol binding. J. Clin. Endocr. 22: 1165, 1962. CrossrefGoogle Scholar39. BEIERWALTESROBBINS WHJ: Familial increase in the thyroxine-binding sites in serum alpha globulin. J. Clin. Invest. 38: 1683, 1959. CrossrefMedlineGoogle Scholar40. FLORSHEIMDOWLINGMEISTERBODFISH WHJTLRE: Familial elevation of serum thyroxine-binding capacity. J. Clin. Endocr. 22: 735, 1962. CrossrefMedlineGoogle Scholar41. SCHEDLCHENGREENEREDD HPPSGD: The renal clearance of plasma cortisol. J. Clin. Endocr. 19: 1223, 1959. CrossrefGoogle Scholar42. BEISELCOSHORTONCHAOFORSHAM WRJJRPVPH: The physiology of urinary cortisol excretion. Submitted to J. Clin. Endocr. Google Scholar43. COPEBLACK CLEG: The reliability of some adrenal function tests. Brit. Med. J. 2: 1117, 1959. CrossrefMedlineGoogle Scholar44. ROSNERCOSBIGLIERIHANEFORSHAM JMJSEGSPH: Diagnostic advantages of free urinary cortisol determinations in suspected adrenal cortical overactivity (abstract). Clin. Res. 10: 89, 1962. Google Scholar45. BONGIOVANNIEBERLEIN AMWR: Determination, recovery, identification and renal clearance of conjugated adrenal corticoids in human peripheral blood. Proc. Soc. Exp. Biol. Med. 89: 281, 1955. CrossrefMedlineGoogle Scholar46. ENGLERTBROWNWILLARDSONWALLACHSIMONS EHDGSEL: Metabolism of free and conjugated 17-hydroxycorticosteroids in subjects with uremia. J. Clin. Endocr. 18: 36, 1958. CrossrefMedlineGoogle Scholar47. PEKKARINENKASANEN AA: Plasma level, urinary excretion and clearance of 17-OHCS in renal patients after intravenous cortisol injection. Acta Endocr. (København) 38: 13, 1961. (Abstract) MedlineGoogle Scholar48. BROWNENGLERT HE: Corticosteroid metabolism in liver disease. Arch. Intern. Med. (Chicago) 107: 773, 1961. CrossrefGoogle Scholar49. SAMUELSBROWNEIK-NESTYLERDOMINGUEZ LTHKFHOV: Extraadrenal factors affecting the levels of 17-hydroxycorticoids in plasma. Ciba Found. Colloq. Endocr. 11: 208, 1957. Google Scholar50. CRANNYKELLEY RLVC: The interpretation of steroid half-life values. A letter to the editor, J. Clin. Endocr. 19: 854, 1959. CrossrefGoogle Scholar51. BEISELDIRAIMONDOROSNERBIGLIERI WRVCJEG: Changes in cortisol binding induced by intravenous cortisol. Clin. Res. 10: 114, 1962. Google Scholar52. CHRISTYFISHMAN NPRA: Studies of the bloodcerebrospinal fluid barrier to cortisol in the dog. J. Clin. Invest. 40: 1997, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Frederick, Maryland and San Francisco, CaliforniaFrom the United States Army Medical Unit, Walter Reed Army Medical Center, Fort Detrick, Frederick, Maryland, and the Metabolic Unit, University of California Hospitals, San Francisco, California.Presented at the Forty-fourth Annual Session of the American College of Physicians, Denver, Colorado, April 1-5, 1963.Requests for reprints should be addressed to Lt. Col. W. R. Beisel, M.D., United States Army Medical Unit, Walter Reed Army Medical Center, Fort Detrick, Frederick, Maryland .*11 beta, 17 alpha, 21 trihydroxy-4-pregnene-3,20 dione, also termed compound F or hydrocortisone. 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