SEROTONIN
1957; American College of Physicians; Volume: 46; Issue: 2 Linguagem: Inglês
10.7326/0003-4819-46-2-425
ISSN1539-3704
Autores Tópico(s)Chemical Reactions and Mechanisms
ResumoEditorial1 February 1957SEROTONINF. J. BORGES, M.D., S. P. BESSMAN, M.D.F. J. BORGES, M.D.Search for more papers by this author, S. P. BESSMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-2-425 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe intestinal tract has long been considered the source of powerful chemical agents. This philosophy was formalized by Metchnikoff, and gave rise to the theory of autointoxication prevalent in the early decades of the twentieth century. Within the last few years workers in many fields in many countries have seen their researches converge upon a potent substance which might well be one of the powerful amines envisioned by Metchnikoff.For the last 100 years it has been known to physiologists that the vasoconstrictor properties of the blood increase when blood clots. This constituted a serious problem for the investigators who...1 GaddumHebbSilverSwan JHCOAA: 5-Hydroxytryptamine, pharmacological action and destruction in perfused lungs, Quart. J. Exper. Physiol. 38: 255, 1953. CrossrefMedlineGoogle Scholar2 RapportGreenPage MMAAIH: Partial purification of the vasoconstrictor in beef serum, J. Biol. Chem. 174: 735, 1948. CrossrefMedlineGoogle Scholar3 Rapport MM: Serum vasoconstrictor (serotonin). The presence of creatine in the complex. A proposed structure of the vasoconstrictor principle, J. Biol. Chem. 180: 961, 1949. CrossrefMedlineGoogle Scholar4 Corcoran AC: Serotonin, J. A. M. A. 161: 1275, 1956. CrossrefGoogle Scholar5 RandReid MG: Source of serotonin in serum, Nature, London, 168: 385, 1951. CrossrefMedlineGoogle Scholar6 VialliErspamer MV: Cellule enterocromaffini e cellule basigranulose acidofile nei vertebrati, Ztschr. f. Zellforsch. u. mikr. Anat. 19: 743, 1933. CrossrefGoogle Scholar7 VialliErspamer MV: Sulle Reazioni Chimiche Colorate Dell' Enteramine, Arch. di sc. biol. 28: 101, 1942. Google Scholar8 Erspamer V: Pharmacology of indolealkylamines, Pharmacol. Rev. 6: 425, 1954. MedlineGoogle Scholar9 ErspamerBoretti VG: Identification and characterization by paper chromatography of enteramine, octopamine, tyramine, histamine and allied substances in extracts of posterior salivary glands of octopoda and in other tissue extracts of vertebrates and invertebrates, Arch. internat. de pharmacodyn. et de therap. 88: 296, 1951. MedlineGoogle Scholar10 ErspamerAsero VB: Identification of enteramine, the specific hormone of the enterochromaffin system as 5-hydroxytryptamine, Nature, London 169: 800, 1952. CrossrefMedlineGoogle Scholar11 Lembeck F: 5-Hydroxytryptamine in a carcinoid tumor, Nature, London 172: 910, 1953. CrossrefGoogle Scholar12 ThorsonBiorckBjorkmanWaldenström AGGJ: Malignant carcinoid of the small intestine, Am. Heart J. 47: 795, 1954. CrossrefMedlineGoogle Scholar13 PernowWaldenstrom BJ: Paroxysmal flushing and other symptoms caused by 5-hydroxytryptamine and histamine in patients with malignant tumors, Lancet 2: 951, 1954. CrossrefGoogle Scholar14 PageCorcoranUdenfriendWeissbach IHACSH: Argentaffinoma as endocrine tumour, Lancet 1: 198, 1955. CrossrefGoogle Scholar15 UdenfriendWeissbachClark SHCT: The estimation of 5-hydroxytryptamine (serotonin) in biological tissues, J. Biol. Chem. 215: 337, 1955. CrossrefMedlineGoogle Scholar16 UdenfriendTitusWeissbach SEH: Identification of 5-hydroxyindole acetic acid in normal urine and a method for its assay, J. Biol. Chem. 216: 499, 1955. CrossrefMedlineGoogle Scholar17 SjoerdsmaWeissbachUdenfriend AHS: Simple test for diagnosis of metastatic carcinoid (argentaffinoma), J. A. M. A. 159: 397, 1955. CrossrefGoogle Scholar18 UdenfriendTitusWeissbachPeterson SEHR: Biogenesis and metabolism of 5-hydroxyindole compounds, J. Biol. Chem. 219: 335, 1956. CrossrefMedlineGoogle Scholar19 BogdanskiWeissbachUdenfriend DFHS: Pharmacological effects of 5-hydroxytryptophane, the precursor of serotonin, Federation Proc. 15: 402, 1956. Google Scholar20 Udenfriend S: Personal communication. Google Scholar21 PletscherShoreBrodie APABB: Serotonin as a mediator of reserpine action in brain, J. Pharmacol. and Exper. Therap. 116: 84, 1956. MedlineGoogle Scholar22 HauerbackSjoerdsmaTerry BJALL: Urinary excretion of the serotonin metabolite 5-hydroxyindoleacetic acid in various clinical conditions, New England J. Med. 255: 270, 1956. CrossrefMedlineGoogle Scholar23 BorgesBessman FSP: Urinary excretion of 5-hydroxyindoleacetic acid. A. Serotonin metabolite, in hypertensive renal vascular disease, Proc. Soc. Exper. Biol. and Med., in press. Google Scholar24 Stoll WA: Lysergsäure—Diaethylamid, ein Phantastikum aus der Mutterkorngroppe, Schweiz. Arch. f. Neurol. u. Psychiat. 60: 279, 1947. Google Scholar25 WooleyShaw DWE: An antiserotonin which is active when fed, J. Pharmacol. and Exper. Therap. 108: 87, 1953. MedlineGoogle Scholar26 WooleyShaw DWE: A biochemical and pharmacological suggestion about certain mental disorders, Proc. Nat. Acad. Sc. 40: 228, 1954. CrossrefMedlineGoogle Scholar27 WooleyShaw DWE: Some neurophysiological aspects of Serotonin, Brit. M. J. 2: 122, 1954. CrossrefMedlineGoogle Scholar28 AminCrawfordGaddum AHTBJH: Distribution of substance P and 5-hydroxytryptamine in the central nervous system of the dog, J. Physiol. 126: 596, 1954. CrossrefMedlineGoogle Scholar29 WaldenstromLjungberg JE: Studies on the functional circulatory influence from metastasizing carcinoid tumours and their possible relation to enteramine production, Acta med. Scandinav. 152: 311, 1955. CrossrefMedlineGoogle Scholar30 BrodiePletscherShore BBAPA: Evidence that serotonine has a role in brain function, Science 122: 918, 1955. CrossrefGoogle Scholar31 BrodiePletscherShore BBAPA: Interaction of reserpine, serotonin, and lysergic acid diethylamide in brain, Science 122: 374, 1955. MedlineGoogle Scholar32 SjoerdsmaSmithStevensonUdenfriend ATETDS: Metabolism of 5-hydroxytryptamine by monoamine oxidase, Proc. Soc. Exper. Biol. and Med. 89: 36, 1955. CrossrefMedlineGoogle Scholar33 BendittRowley EPDA: Antagonism of 5-hydroxytryptamine by chlorpromazine, Science 123: 24, 1956. CrossrefMedlineGoogle Scholar34 ColeBertino GBGG: Effect of chlorpromazine on excretion of 5-hydroxymdoleacetic acid in a patient with malignant carcinoid, Proc. Soc. Exper. Biol. and Med. 93: 100, 1956. CrossrefMedlineGoogle Scholar35 LangfittHartMarrazzi TWERAS: Relation between cerebral synoptic action of mesialine, indoles, and tranquilizers, Federation Proc. 15: 495, 1956. Google Scholar36 WaldenströmLjungberg JE: Studies on the functional circulatory influence from metastasizing carcinoid tumours and their possible relation to enteramine production. I. Symptoms of carcinoidosis, Acta med. Scandinav. 152: 293, 1955. CrossrefMedlineGoogle Scholar37 McKusick VA: Carcinoid cardiovascular disease, Bull. Johns Hopkins Hosp. 98: 13, 1956. MedlineGoogle Scholar38 Reid G: Circulatory effects of 5-hydroxytryptamine, J. Physiol. 118: 435, 1952. CrossrefMedlineGoogle Scholar39 PageMcCubbin IJW: The variable arterial pressure response to serotonin in laboratory animals and man, Circulation Res. 1: 354, 1953. CrossrefMedlineGoogle Scholar40 ComroeVan LinganStroudRoncoroni JHBRCA: Reflex and direct cardiopulmonary effects of 5-hydroxytryptamine, Am. J. Physiol. 173: 379, 1953. CrossrefMedlineGoogle Scholar41 Herxheimer H: Influence of 5-hydroxytryptamide on bronchial function, J. Physiol. 122: 490, 1953. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe intracranial injection of drugs in goldfish. I: Hallucinogens and their antagonism to smooth muscle activityThe General Appearance (Habitus)Biochemische, funktionelle und morphologische Organveränderungen durch Beeinflussung des 5-Hydroxytryptamin-StoffwechselsCarcinoid syndrome produced by metastasizing bronchial adenomaREFERENCESGASTRIC SECRETION AS INFLUENCED BY RAUWOLFIA ALKALOIDS*EDWARD M. SCHNEIDER, M.D., MERVIN L. CLARK, M.D. 1 February 1957Volume 46, Issue 2Page: 425-430KeywordsSerotoninThrombosis Issue Published: 1 February 1957 PDF DownloadLoading ...
Referência(s)