Portal de Periódicos da CAPES

MONDAY 29 NOVEMBER 2010

2010; Wiley; Volume: 4; Issue: s1 Linguagem: Inglês

10.1111/j.1751-7893.2010.00205.x

1751-7893

Jean Addington, K Ba, T Cadenhead, Robert E. Cannon, T Heinssen, Derek J. McGlashan, Martin Perkins, E Tsuang, Susan P. Walker, L Woods, M. Weiser, Stephan Ruhrmann, Alison R. Yung, A. Livny-Ezer, Avi Reichenberg, G. Lubin, Moti Shmushkevich, Eytan Bachar, Michael Davidson, Frauke Schultze‐Lutter, Rkr Salokangas, Don Linszen, Max Birchwood, Georg Juckel, Sharon Lewis, Joachim Klosterkötter, Barnaby Nelson, Hok Pan Yuen, Daniela Spiliotacopoulos, Ashleigh Lin, Annie Bruxner, C Broussard, Magenta Simmons, A. Thompson, G. Paul Amminger, Patrick D. McGorry, Julie Evensen, Jan Ivar Røssberg, Ulrik Haahr, Inge Joa, Jesper Johannesen, Johannes Langeveld, Torben Larsen, W. E. Tjon a Ten, Velden Hegelstad, Ingrid Melle, Stein Opjordsmoen, Bjørn Rishovd Rund, Erik Simonsen, Per Vaglum, Svein Friis, T. H. McGlashan, W Hegelstad Ten Velden,

Child and Adolescent Psychosocial and Emotional Development

Background: A major focus in high-risk research is determining the risk of conversion to psychosis and developing algorithms of prediction.Although the rates of conversion vary across samples, it is always a minority of the samples, i.e. 85% to 50% of putatively prodromal samples do not go on, at least in the duration of the studies (usually 1 year) to develop psychosis Method: The North American Prodrome Longitudinal Study (NAPLS 1) is an eight-site prospective, longitudinal study with up to 2.5 years of follow-up of 291 prospectively identifi ed treatment-seeking patients meeting Structured Interview for Prodromal Syndromes (SIPS) criteria. Results:In this sample, 35% made the transition to a full-blown psychotic illness.Predictors of conversion included suspiciousness, unusual thought, substance use, genetic risk and poor functioning.However, the sample being studied included 136 individuals who had at least 1 year of follow-up, had not made the transition to psychosis within the duration of the study and were not on any antipsychotics.For this group, there were signifi cant improvements in all symptoms (P < 0.0001) and functioning (P < 0.01).Less than 50% continued to have minimal levels of attenuated positive symptoms. Conclusion:Help-seeking individuals who meet prodromal criteria appear to fall into three groups -those who develop a psychotic illness, those who improve and those who continue to have sub-threshold psychotic symptoms.This has implications for the kinds of treatments we may offer and how we conceptualize those who have a prodromal risk syndrome.