Safety and efficacy of iron compounds (E1) as feed additives for all animal species: ferrous carbonate; ferric chloride, hexahydrate; ferrous fumarate; ferrous sulphate, heptahydrate; ferrous sulphate, monohydrate; ferrous chelate of amino acids, hydrate; ferrous chelate of glycine, hydrate, based on a dossier submitted by FEFANA asbl
2016; Wiley; Volume: 14; Issue: 2 Linguagem: Inglês
10.2903/j.efsa.2016.4396
ISSN1831-4732
Tópico(s)Pesticide Exposure and Toxicity
ResumoEFSA JournalVolume 14, Issue 2 4396 OpinionOpen Access Safety and efficacy of iron compounds (E1) as feed additives for all animal species: ferrous carbonate; ferric chloride, hexahydrate; ferrous fumarate; ferrous sulphate, heptahydrate; ferrous sulphate, monohydrate; ferrous chelate of amino acids, hydrate; ferrous chelate of glycine, hydrate, based on a dossier submitted by FEFANA asbl EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Search for more papers by this author EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Search for more papers by this author First published: 18 February 2016 https://doi.org/10.2903/j.efsa.2016.4396Citations: 13 Panel members: Gabriele Aquilina, Giovanna Azimonti, Vasileios Bampidis, Maria de Lourdes Bastos, Georges Bories, Andrew Chesson, Pier Sandro Cocconcelli, Gerhard Flachowsky, Jürgen Gropp, Boris Kolar, Maryline Kouba, Secundino López Puente, Marta López-Alonso, Alberto Mantovani, Baltasar Mayo, Fernando Ramos, Guido Rychen, Maria Saarela, Roberto Edoardo Villa, Robert John Wallace and Pieter Wester Correspondence:feedap@efsa.europa.eu Acknowledgement: The Panel wishes to thank the members of the Working Group on Trace Elements, including Noël Dierick, Mikolaj Antoni Gralak, Christer Hogstrand, Lubomir Leng and Johannes Westendorf, for the preparatory work on this scientific opinion. Amendment: This scientific opinion has been amended to record the addendum of the EURL report on footnote 9. Adoption date: 27 January 2016 Published date: 18 February 2016 Question number: EFSA-Q-2012-00491 On request from: European Commission Amended: 22 June 2017 Amended: 2 March 2018 AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) has assessed seven iron compounds: ferrous carbonate, ferric chloride, hexahydrate, ferrous fumarate, ferrous sulphate, heptahydrate, ferrous sulphate, monohydrate, ferrous chelate of amino acids, hydrate and ferrous chelate of glycine, hydrate. A review of the literature concerning maximum safe levels in animals indicated that 450 mg total iron/kg appears to be safe for bovines and poultry, 600 mg total iron/kg for pet animals; these values are lower than the corresponding currently authorised maximum contents. Because of insufficient data, the FEEDAP Panel is not in a position to derive a maximum safe iron concentration in feed for horses or fish. No concerns for consumer safety are expected from the use of the iron compounds under application up to the EU maximum authorised level. Ferrous sulphates and ferric chloride hexahydrate are corrosive upon contact with mucosae and irritants to skin and respiratory tract. Ferrous fumarate, ferrous carbonate, ferrous chelate of glycine, hydrate and ferrous chelate of amino acids, hydrate are considered as irritants to skin, eyes and mucous membranes. Due to the presence of nickel, all additives under assessment should be considered as dermal and respiratory sensitisers. Handling ferrous carbonate and ferrous fumarate may lead to an iron exposure by inhalation exceeding the threshold limit value. Ferrous fumarate, ferrous carbonate and ferrous chelate of amino acids hydrate pose a risk to users by inhalation due to the levels of nickel. The supplementation of feed with the iron compounds under assessment is not expected to pose an environmental risk. 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