Treatment of Gastric MALT Lymphoma by Helicobacter pylori Eradication: A Study Controlled by Endoscopic Ultrasonography
1998; Lippincott Williams & Wilkins; Volume: 93; Issue: 5 Linguagem: Inglês
10.1111/j.1572-0241.1998.215_a.x
ISSN1572-0241
AutoresCarlos Nobre‐Leitão, Pedro Lage, Marília Cravo, José Cabeçadas, Paula Chaves, A Alberto-Santos, João Correia, Janine Soares, F. Costa-Mira,
Tópico(s)Lymphoma Diagnosis and Treatment
ResumoObjective: Previous studies have demonstrated a link betweenHelicobacter pyloriinfection and low grade B-cell gastric MALT lymphoma. The aim of this study was to evaluate the effect ofHelicobacter pylorieradication in 17 patients with low grade B-cell gastric MALT lymphoma stage EI. Methods: For disease staging EUS and CT scan were systematically performed. Eight patients were excluded from the present series because stage EII disease was diagnosed. To demonstrate B-cell monoclonality, immunohistochemistry and polymerase chain reaction were used.H. pylorieradication was performed with triple therapy. Results: H. pyloriwas eradicated in all patients after first (n = 15) or second line (n = 2) treatment. Histologic regression of lymphoma was observed in all patients after a median period of 2 mo. Disappearance of monoclonality according to polymerase chain reaction took significantly longer (7 mo). At the end of the study, four of 16 patients still exhibited persistent monoclonal bands. Relapse of lymphoma occurred in two patients associated withH. pylorireinfection/recrudescence. Conclusions: Eradication ofH. pyloriseems to be an effective therapy in patients with stage EI gastric MALT lymphoma, although long-term results are still uncertain. Endoscopic ultrasonography is useful for a more accurate staging of the disease. The clinical significance of detecting monoclonality by polymerase chain reaction remains to be determined.
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