Clinical response and temporal patterns of acute cellular rejection: relationship to chronic transplant nephropathy
1998; Springer Science+Business Media; Volume: 11; Issue: s1 Linguagem: Inglês
10.1111/j.1432-2277.1998.tb01189.x
ISSN1432-2277
AutoresShazad Q. Ashraf, N. Parrott, Stephen A. Roberts, R. W. G. Johnson, P. A. Dyer,
Tópico(s)Organ Donation and Transplantation
ResumoTransplant InternationalVolume 11, Issue S1 p. S5-S9 Free to Read Clinical response and temporal patterns of acute cellular rejection: relationship to chronic transplant nephropathy S. Ashraf, S. Ashraf Renal Transplant Unit, Manchester Royal Infirmary, Manchester, M13 9WL, UKSearch for more papers by this authorN.R. Parrott, Corresponding Author N.R. Parrott Renal Transplant Unit, Manchester Royal Infirmary, Manchester, M13 9WL, UK*Renal Transplant Unit, Manchester Royal Infirmary, Manchester, M13 9WL, UKSearch for more papers by this authorI. Roberts, I. Roberts Department of Histopathology, Manchester Royal Infirmary, Manchester, UKSearch for more papers by this authorR.W.G. Johnson, R.W.G. Johnson Renal Transplant Unit, Manchester Royal Infirmary, Manchester, M13 9WL, UKSearch for more papers by this authorP. Dyer, P. Dyer North West Regional Tissue Typing Laboratory. St Mary's Hospital, Manchester, UKSearch for more papers by this author S. Ashraf, S. Ashraf Renal Transplant Unit, Manchester Royal Infirmary, Manchester, M13 9WL, UKSearch for more papers by this authorN.R. Parrott, Corresponding Author N.R. Parrott Renal Transplant Unit, Manchester Royal Infirmary, Manchester, M13 9WL, UK*Renal Transplant Unit, Manchester Royal Infirmary, Manchester, M13 9WL, UKSearch for more papers by this authorI. Roberts, I. Roberts Department of Histopathology, Manchester Royal Infirmary, Manchester, UKSearch for more papers by this authorR.W.G. Johnson, R.W.G. Johnson Renal Transplant Unit, Manchester Royal Infirmary, Manchester, M13 9WL, UKSearch for more papers by this authorP. Dyer, P. Dyer North West Regional Tissue Typing Laboratory. St Mary's Hospital, Manchester, UKSearch for more papers by this author First published: 02 June 2008 https://doi.org/10.1111/j.1432-2277.1998.tb01189.xCitations: 9AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Abstract The association between acute cellular rejection (ACR) and the development of chronic rejection has been the subject of much debate. Studies have suggested that the two phenomena may be linked, or, conversely that there may be no association at all. In order to clarify this relationship the outcome of 284 renal allografts were examined. The transplants were all performed at a single institution between April 1989 and December 1991, allowing a minimum follow up of 5 years. ACR was classified into three clinical response groups: (1) fully responsive to therapy (type 1 ACR), (2) partially responsive (type 2) and (3) ACR requiring treatment with ATG or OKT3 (type 3). Acute and chronic rejection were determined by histological (Banff) criteria. Chronic transplant nephropathy (CTN) occurred significantly more frequently in those with late ACR after day 60 than in those who had early rejection (53.5% versus 17.3%, respectively, P < 0.00001). Acute rejection that was fully responsive to therapy (type 1) had no association with CTN, but partially responsive rejection and rejection requiring seconD-line treatment were both significantly associated with CTN (P < 0.0001 and P < 0.001, respectively). 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