HLA-B12 in alopecia areata
1977; American Medical Association; Volume: 113; Issue: 12 Linguagem: Inglês
10.1001/archderm.113.12.1716
ISSN1538-3652
Autores Tópico(s)Autoimmune Bullous Skin Diseases
ResumoAlopecia areata is a disease of unknown origin with some degree of hereditary transmission. We have analyzed the HLA antigens 1 in 47 unrelated Finnish patients with alopecia areata. Subjects The series comprised of 22 women and seven men with alopecia areata. These patients had patchy alopecia of the scalp. Six men and eight women had alopecia totalis, ie, total hair loss of the scalp. Two men and two women had alopecia universalis, ie, hair loss of the entire body. Results The HLA phenotype frequencies in the 47 patients and in a Finnish control population 2 are shown in Table 1. The increase of HLA-B12 was significant (χ 2 = 15.67, P = .000075, P = .0018 after the correction for the 24 HLA specificities, relative risk = 3.59). In the 29 patients with patchy alopecia areata, the association with HLA-B12 was even stronger (χ2 = 20.80, P = .0000051, P = .00012 after correction, relative risk
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