Effect of single and repeated electroconvulsive shock on serotonergic system in rat brain—I metabolic studies
1980; Elsevier BV; Volume: 19; Issue: 11 Linguagem: Inglês
10.1016/0028-3908(80)90100-8
ISSN1873-7064
Autores Tópico(s)Coordination Chemistry and Organometallics
ResumoEffect of single and repeated (once daily for 10 days) electroconvulsive shock (ECS) (150V, 0.4 sec) on 5-hydroxyltryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels under various pharmacological conditions in the hypothalamus (HTh) and forebrain (F) of the rat brain was investigated. Single and repeated ECS increased significantly the accumulation of 5-HT in both brain regions in iproniazide-, and iproniazide plus l-tryptophan-treated rats after 1 hr, but not after 24 and 48 hr. The disappearance of 5-HT in p-chlorophenylalanine-treated animals was potentiated by both ECS regimens only at 1 hr. Single and repeated ECS increased 5-HIAA levels in both hypothalamus and forebrain in rats pretreated with probenecid, and in rats without any drug treatment. It is concluded that single and repeated ECS increased the synthesis and the catabolism of 5-HT in the rat brain only at 1 hr. There was neither qualitative nor quantitative difference in effects on 5-HT metabolism between both ECS regimens.
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