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Fast Production of Highly Reactive No‐Carrier‐Added [ 18 F]Fluoride for the Labeling of Radiopharmaceuticals

2010; Wiley; Volume: 122; Issue: 18 Linguagem: Inglês

10.1002/ange.200906341

1521-3757

Christian Lemaire, Joël Aerts, Samuël Voccia, Lionel Libert, F. Mercier, David Goblet, Alain Plenevaux, André Luxen,

Chemical Reactions and Isotopes

Angewandte ChemieVolume 122, Issue 18 p. 3229-3232 Zuschrift Fast Production of Highly Reactive No-Carrier-Added [18F]Fluoride for the Labeling of Radiopharmaceuticals† Christian F. Lemaire Dr., Christian F. Lemaire Dr. christian.lemaire@ulg.ac.be University of Liège, B30—Cyclotron Research Center, Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this authorJoël J. Aerts Dr., Joël J. Aerts Dr. University of Liège, B30—Cyclotron Research Center, Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this authorSamuel Voccia Dr., Samuel Voccia Dr. Trasis sa Voie de Liège, 2, 4053 Embourg (Belgium)Search for more papers by this authorLionel C. Libert, Lionel C. Libert University of Liège, B30—Cyclotron Research Center, Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this authorFrédéric Mercier Dr., Frédéric Mercier Dr. University of Liège, B30—Cyclotron Research Center, Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this authorDavid Goblet, David Goblet University of Liège, B30—Cyclotron Research Center, Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this authorAlain R. Plenevaux Dr., Alain R. Plenevaux Dr. University of Liège, B30—Cyclotron Research Center, Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this authorAndré J. Luxen Prof., André J. Luxen Prof. University of Liège, B30—Cyclotron Research Center, Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this author Christian F. Lemaire Dr., Christian F. Lemaire Dr. christian.lemaire@ulg.ac.be University of Liège, B30—Cyclotron Research Center, Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this authorJoël J. Aerts Dr., Joël J. Aerts Dr. University of Liège, B30—Cyclotron Research Center, Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this authorSamuel Voccia Dr., Samuel Voccia Dr. Trasis sa Voie de Liège, 2, 4053 Embourg (Belgium)Search for more papers by this authorLionel C. Libert, Lionel C. Libert University of Liège, B30—Cyclotron Research Center, Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this authorFrédéric Mercier Dr., Frédéric Mercier Dr. University of Liège, B30—Cyclotron Research Center, Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this authorDavid Goblet, David Goblet University of Liège, B30—Cyclotron Research Center, Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this authorAlain R. Plenevaux Dr., Alain R. Plenevaux Dr. University of Liège, B30—Cyclotron Research Center, Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this authorAndré J. Luxen Prof., André J. Luxen Prof. University of Liège, B30—Cyclotron Research Center, Sart Tilman, 4000 Liège (Belgium), Fax: (+32) 4-366-2946Search for more papers by this author First published: 09 April 2010 https://doi.org/10.1002/ange.200906341Citations: 7 † This project was supported by the Fonds de la Recherche Scientifique, the University of Liège (Fonds spéciaux, Crédit classique, and Fonds Rahier). A.R.P. is a Senior Research Associate of the Fonds de la Recherche Scientifique (F.R.S.–FNRS, Brussels, Belgium). Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Für die 18F-Markierung von Radiopharmaka benötigt man annähernd wasserfreie [18F]Fluorid-Lösungen, doch um [18F]F− von Anionaustauscherharzen zu waschen, werden üblicherweise wässrige K2CO3-Lösungen verwendet. Ersetzt man K2CO3 durch starke organische Basen wie die Phosphazenbase P2Et (deren konjugierte Säure hier abgebildet ist), so lässt sich hoch reaktives [18F]F− ohne eine azeotrope Wasserverdampfung zurückgewinnen. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description ange_200906341_sm_miscellaneous_information.pdf197.3 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume122, Issue18April 19, 2010Pages 3229-3232 This is the German version of Angewandte Chemie. Note for articles published since 1962: Do not cite this version alone. Take me to the International Edition version with citable page numbers, DOI, and citation export. We apologize for the inconvenience. RelatedInformation