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Role of gene regulation in song circuit development and song learning

1997; Wiley; Volume: 33; Issue: 5 Linguagem: Inglês

10.1002/(sici)1097-4695(19971105)33

1097-4695

David F. Clayton,

Animal Vocal Communication and Behavior

Journal of NeurobiologyVolume 33, Issue 5 p. 549-571 Role of gene regulation in song circuit development and song learning David F. Clayton, Corresponding Author David F. Clayton Department of Cell and Structural Biology, Neuroscience Program and the Beckman Institute, B107 Chemical/Life Sciences Labs, University of Illinois, 601 S. Goodwin, Urbana, Illinois 61801Department of Cell and Structural Biology, Neuroscience Program and the Beckman Institute, B107 Chemical/Life Sciences Labs, University of Illinois, 601 S. Goodwin, Urbana, Illinois 61801Search for more papers by this author David F. Clayton, Corresponding Author David F. Clayton Department of Cell and Structural Biology, Neuroscience Program and the Beckman Institute, B107 Chemical/Life Sciences Labs, University of Illinois, 601 S. Goodwin, Urbana, Illinois 61801Department of Cell and Structural Biology, Neuroscience Program and the Beckman Institute, B107 Chemical/Life Sciences Labs, University of Illinois, 601 S. Goodwin, Urbana, Illinois 61801Search for more papers by this author First published: 07 December 1998 https://doi.org/10.1002/(SICI)1097-4695(19971105)33:5 3.0.CO;2-4Citations: 74AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract The songbird has emerged as an important model for study of brain-behavior relationships by virtue of its rich natural advantages and from the pioneering efforts of explorers using anatomical and behavioral approaches. Now, molecular biology is providing a new and complementary paradigm for discerning songbird brain organization and function. Here, I review the work over the last 10 years that has laid the foundation for approaching songbird biology from the molecular perspective. As a result of this work, specific hypotheses can now be framed and tested regarding the mechanisms behind song circuit formation, behavioral plasticity, and the boundaries of adaptability. Age-related changes in more than 15 molecules have been observed in the song system of juvenile zebra finches, and these changes seem to define specific phases in circuit development. In adult songbirds, ordinary song-related activities such as singing and listening cause dramatic increases in gene expression in brain areas specific to each activity. The sensitivity of gene activation is modulated as a result of experience in adulthood and also changes during juvenile song learning. These studies have provided unexpected insights into the functional organization of the song circuit and the potential role of extrinsic modulatory systems in directing and limiting plastic change in the brain. With this rich base of knowledge, and techniques of gene manipulation on the horizon, answers to old questions seem within our reach: What sets the boundaries of neural plasticity? What limits learning? © 1997 John Wiley & Sons, Inc. J Neurobiol 33: 549–571, 1997 References Aamodt, S. M., Kozlowski, M. R., Nordeen, E. J., and Nordeen, K. W. (1992). Distribution and developmental change in [3H] MK-801 binding within zebra finch song nuclei. J. Neurobiol. 23: 997–1005. 10.1002/neu.480230806 CASPubMedWeb of Science®Google Scholar Aamodt, S. M., Nordeen, E. J., and Nordeen, K. W. (1995). Early isolation from conspecific song does not affect the normal developmental decline of N-methyl-D-aspartate receptor binding in an avian song nucleus. J. 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