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Effects of Saikosaponins on Liver Tyrosine Aminotransferase Activity induced by Cortisone in Adrenalectomized Rats

1985; Thieme Medical Publishers (Germany); Volume: 51; Issue: 05 Linguagem: Inglês

10.1055/s-2007-969531

1439-0221

Mitsuyoshi Hashimoto, Kayoko Inada, Hiroji Ohminami, Yoshiyuki Kimura, Hiromichi Okuda, Shigeru Arichi,

Food Quality and Safety Studies

Liver tyrosine aminotransferase activity is known to be induced by administration of steroids to adrenalectomized rats. When saikosaponin a, b1, b2, b3, b4, c, d or f was injected intraperitoneally into adrenalectomized rats, no induction of liver tyrosine aminotransferase activity was observed. Administration of a low dose of cortisone (6.4 µmol/kg) to adrenalectomized rats also did not induce liver tyrosine aminotransferase. But this enzyme was induced on administration of this low dose of cortisone with saikosaponen a (6.4 or 12.8 µmol/kg), d (6.4 or 12.8 µmol/kg) or f (12.8 µmol/kg). The sturcture-activity relationship of the effects of various Saikosaponins on the action of cortisone is discuused.