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Oxidation of Flavanones with Thallium(III) Nitrate(ttn). A Convenient Route to Flavones

1982; Taylor & Francis; Volume: 12; Issue: 12 Linguagem: Inglês

10.1080/00397918208061928

1532-2432

Rajender S. Varma, Manju Varma,

Neurological Disease Mechanisms and Treatments

Abstract During the course of our work1–2 on thallium(III) nitrate(TTN) oxidation of chalcones we synthesised some naphthalene analogues3 of isoflavone. While preparing a phenanthrene analogue the reaction of 2-(9-phenanthrenyl)-chroman-4-one(1) with thallium(III) nitrate was examined; this gave the corresponding chromone (2) in 72% yield. Further exploration of this oxidation has revealed that the formation of (2) is representative of a general step suitable for the preparation of a variety of flavones from flavanones.