Pharmacokinetics of ICG and HPPH-car for the Detection of Normal and Tumor Tissue Using Fluorescence, Near-infrared Reflectance Imaging: A Case Study ¶
2007; Wiley; Volume: 72; Issue: 1 Linguagem: Inglês
10.1562/0031-8655(2000)0720094poiahc2.0.co2
ISSN1751-1097
AutoresMichael Gurfinkel, Alan Bruce Thompson, William Ralston, Tamara L. Troy, Ana L. Moore, Thomas A. Moore, J. Devens Gust, Derreck Tatman, Jeffery S. Reynolds, Bruce A. Muggenburg, Kristin Nikula, Ravindra Pandey, R. H. Mayer, Daniel J. Hawrysz, Eva M. Sevick‐Muraca,
Tópico(s)Optical Imaging and Spectroscopy Techniques
ResumoPhotochemistry and PhotobiologyVolume 72, Issue 1 p. 94-102 Pharmacokinetics of ICG and HPPH-car for the Detection of Normal and Tumor Tissue Using Fluorescence, Near-infrared Reflectance Imaging: A Case Study ¶ Michael Gurfinkel, Michael Gurfinkel School of Chemical Engineering, Purdue University, West Lafayette, INSearch for more papers by this authorAlan B. Thompson, Alan B. Thompson School of Chemical Engineering, Purdue University, West Lafayette, INSearch for more papers by this authorWilliam Ralston, William Ralston Mallinckrodt Medical, Inc., St. Louis, MOSearch for more papers by this authorTamara L. Troy, Tamara L. Troy School of Chemical Engineering, Purdue University, West Lafayette, INSearch for more papers by this authorAna L. Moore, Ana L. Moore Department of Chemistry & Biochemistry; Arizona State University, Tempe, AZSearch for more papers by this authorThomas A. Moore, Thomas A. Moore Department of Chemistry & Biochemistry; Arizona State University, Tempe, AZSearch for more papers by this authorJ. Devens Gust, J. Devens Gust Department of Chemistry & Biochemistry; Arizona State University, Tempe, AZSearch for more papers by this authorDerreck Tatman, Derreck Tatman Department of Chemistry & Biochemistry; Arizona State University, Tempe, AZSearch for more papers by this authorJeffery S. Reynolds, Jeffery S. Reynolds School of Chemical Engineering, Purdue University, West Lafayette, INSearch for more papers by this authorBruce Muggenburg, Bruce Muggenburg Lovelace Respiratory Research Institute, Albuquerque, NMSearch for more papers by this authorKristin Nikula, Kristin Nikula Lovelace Respiratory Research Institute, Albuquerque, NMSearch for more papers by this authorRavindra Pandey, Ravindra Pandey Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, NYSearch for more papers by this authorRalf H. Mayer, Ralf H. Mayer School of Chemical Engineering, Purdue University, West Lafayette, INSearch for more papers by this authorDaniel J. Hawrysz, Daniel J. Hawrysz School of Chemical Engineering, Purdue University, West Lafayette, INSearch for more papers by this authorEva M. Sevick-Muraca, Corresponding Author Eva M. Sevick-Muraca School of Chemical Engineering, Purdue University, West Lafayette, IN Chemical Engineering Department, Texas A&M University, College Station, TX *To whom correspondence should be addressed at: Chemical Engineering Department, Zachry Engineering Center, Room 337, Texas A&M University, College Station, TX 77843-3122, USA. Fax: 979-845-6446; [email protected]Search for more papers by this author Michael Gurfinkel, Michael Gurfinkel School of Chemical Engineering, Purdue University, West Lafayette, INSearch for more papers by this authorAlan B. Thompson, Alan B. Thompson School of Chemical Engineering, Purdue University, West Lafayette, INSearch for more papers by this authorWilliam Ralston, William Ralston Mallinckrodt Medical, Inc., St. Louis, MOSearch for more papers by this authorTamara L. Troy, Tamara L. Troy School of Chemical Engineering, Purdue University, West Lafayette, INSearch for more papers by this authorAna L. Moore, Ana L. Moore Department of Chemistry & Biochemistry; Arizona State University, Tempe, AZSearch for more papers by this authorThomas A. Moore, Thomas A. Moore Department of Chemistry & Biochemistry; Arizona State University, Tempe, AZSearch for more papers by this authorJ. Devens Gust, J. Devens Gust Department of Chemistry & Biochemistry; Arizona State University, Tempe, AZSearch for more papers by this authorDerreck Tatman, Derreck Tatman Department of Chemistry & Biochemistry; Arizona State University, Tempe, AZSearch for more papers by this authorJeffery S. Reynolds, Jeffery S. Reynolds School of Chemical Engineering, Purdue University, West Lafayette, INSearch for more papers by this authorBruce Muggenburg, Bruce Muggenburg Lovelace Respiratory Research Institute, Albuquerque, NMSearch for more papers by this authorKristin Nikula, Kristin Nikula Lovelace Respiratory Research Institute, Albuquerque, NMSearch for more papers by this authorRavindra Pandey, Ravindra Pandey Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, NYSearch for more papers by this authorRalf H. Mayer, Ralf H. Mayer School of Chemical Engineering, Purdue University, West Lafayette, INSearch for more papers by this authorDaniel J. Hawrysz, Daniel J. Hawrysz School of Chemical Engineering, Purdue University, West Lafayette, INSearch for more papers by this authorEva M. Sevick-Muraca, Corresponding Author Eva M. Sevick-Muraca School of Chemical Engineering, Purdue University, West Lafayette, IN Chemical Engineering Department, Texas A&M University, College Station, TX *To whom correspondence should be addressed at: Chemical Engineering Department, Zachry Engineering Center, Room 337, Texas A&M University, College Station, TX 77843-3122, USA. Fax: 979-845-6446; [email protected]Search for more papers by this author First published: 01 May 2007 https://doi.org/10.1562/0031-8655(2000)0720094POIAHC2.0.CO2Citations: 13 ¶ Posted on the web on 28 April 2000. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat ABSTRACT We present in vivo fluorescent, near-infrared (NIR), reflectance images of indocyanine green (ICG) and carotene-conjugated 2-devinyl-2-(1-hexyloxyethyl) pyropheophorbide (HPPH-car) to discriminate spontaneous canine adenocarcinoma from normal mammary tissue. Following intravenous administration of 1.0 mg kg−1 ICG or 0.3 mg kg−1 HPPH-car into the canine, a 25 mW, 778 nm or 70 mW, 660 nm laser diode beam, expanded by a diverging lens to approximately 4 cm in diameter, illuminated the surface of the mammary tissue. Successfully propagating to the tissue surface, ICG or HPPH-car fluorescence generated from within the tissue was collected by an image-intensified, charge-coupled device camera fitted with an 830 or 710 nm bandpass interference filter. Upon collecting time-dependent fluorescence images at the tissue surface overlying both normal and diseased tissue volumes, and fitting these images to a pharmacokinetic model describing the uptake (wash-in) and release (wash-out) of fluorescent dye, the pharmacokinetics of fluorescent dye was spatially determined. Mapping the fluorescence intensity owing to ICG indicates that the dye acts as a blood pool or blood persistent agent, for the model parameters show no difference in the ICG uptake rates between normal and diseased tissue regions. The wash-out of ICG was delayed for up to 72 h after intravenous injection in tissue volumes associated with disease, because ICG fluorescence was still detected in the diseased tissue 72 h after injection. In contrast, HPPH-car pharmacokinetics illustrated active uptake into diseased tissues, perhaps owing to the overexpression of LDL receptors associated with the malignant cells. HPPH-car fluorescence was not discernable after 24 h. This work illustrates the ability to monitor the pharmacokinetic delivery of NIR fluorescent dyes within tissue volumes as great as 0.5–1 cm from the tissue surface in order to differentiate normal from diseased tissue volumes on the basis of parameters obtained from the pharmacokinetic models. REFERENCES 1 Rokahr, I., S. Andersson-Engels, S. Svanberg, M. D'Hallewin, L. Baert, I. Wang, K. Svanberg (1995) Optical detection of human urinary bladder carcinoma utilising tissue autofluorescence and protoporphyrin IX-induced fluorescence following low dose ALA instillation. Proc. SPIE, 2627, 2–12. 10.1117/12.228894 Web of Science®Google Scholar 2 Nilsson, A. M., C. S. von Holstein, S. Andersson-Engels, R. Willen, B. Walther, K. Svanberg (1995) Clinical detection studies of Barrett's metaplasia and oesophageal adenocarcinoma by means of laser-induced fluorescence. Proc. SPIE, 2627, 49–56. 10.1117/12.228903 Web of Science®Google Scholar 3 Af Klinteberg, C., A. M. K. Enejder, I. Wang, S. Andersson-Engels, S. Svanberg, K. Svanberg 1999 Kinetic fluorescence studies of 5-aminolaevulinic acid-induced protoporphyrin IX accumulation in basal cell carcinomas J. Photochem. Photobiol. B: Biol 49 2-3 120–128 10.1016/S1011-1344(99)00045-7 PubMedWeb of Science®Google Scholar 4 Wagnieres, G., J. Mizeret, A. Studzinski, H. van den Bergh 1997 Frequency-domain fluorescence lifetime imaging for endoscopic clinical cancer photodetection: apparatus design and preliminary results J. Fluoresc 7 1 75–83 10.1007/BF02764580 Google Scholar 5 Farrell, T. J., R. P. Hawkes, M. S. Patterson, B. C. Wilson 1998 Modeling of photosensitizer fluorescence emission and photobleaching for photodynamic therapy dosimetry Appl. Opt 37 31 7168–7183 10.1364/AO.37.007168 CASPubMedWeb of Science®Google Scholar 6 Potter, W. R., D. A. Bellnier, T. J. Dougherty (1992) Optical methods for in-vivo pharmacokinetics. Proc. SPIE, 1645, 166–170. 10.1117/12.60939 Web of Science®Google Scholar 7 Bigio, I. J., J. R. Mourant, G. Los (1999) Elastic-scattering spectroscopy for quantitative measurement of chemotherapy and PDT drug concentrations in vivo. Proc. SPIE, 3568, 26–30. 10.1117/12.336840 Web of Science®Google Scholar 8 Wagnieres G. A., W. M. Star, B. C. Wilson (1998) In vivo fluorescence spectroscopy and imaging for oncological applications. Photochem. Photobiol, 68, 603–632. 10.1111/j.1751-1097.1998.tb02521.x CASPubMedWeb of Science®Google Scholar 9 Reynolds, J. S., T. L. Troy, R. H. Mayer, A. B. Thompson, D. J. Waters, K. K. Cornell, P. W. Snyder, E. M. Sevick-Muraca (1999) Imaging of spontaneous canine mammary tumors using fluorescent contrast agents. Photochem. Photobiol, 70, 87–94. 10.1111/j.1751-1097.1999.tb01953.x CASPubMedWeb of Science®Google Scholar 10 Sevick-Muraca, E. M., G. Lopez, J. S. Reynolds, T. L. Troy, C. L. Hutchinson (1997) Fluorescence and absorption contrast mechanisms for biomedical optical imaging using frequency-domain techniques. Photochem. Photobiol, 66, 55–64. 10.1111/j.1751-1097.1997.tb03138.x CASPubMedWeb of Science®Google Scholar 11 Li, X., B. Chance, A. G. Yodh 1998 Fluorescent heterogeneities in turbid media: limits for detection, characterization, and comparison with absorption Appl. Opt 37 28 6833–6844 10.1364/AO.37.006833 PubMedWeb of Science®Google Scholar 12 Cubeddu, R., G. Canti, A. Pifferi, P. Taroni, G. Valentini (1997) Fluorescence lifetime imaging of experimental tumors in hematoporphyrin derivative-sensitized mice. Photochem. Photobiol, 66, 229–236. 10.1111/j.1751-1097.1997.tb08648.x CASPubMedWeb of Science®Google Scholar 13 Pandey, R. K., A. B. Sumlin, W. R. Potter, D. A. Bellnier, B. W. Henderson, S. Constantine, M. Aoudia, M. R. Rodgers, K. M. Smith, T. J. Dougherty (1996) Structure and photodynamic efficacy among alkyl ether analogues of chlorophyll-a derivatives. Photochem. Photobiol, 63, 194–205. 10.1111/j.1751-1097.1996.tb02442.x Web of Science®Google Scholar 14 Henderson, B. W., D. A. Bellnier, W. R. Graco, A. Sharma, R. K. Pandey, L. Vaughan, K. Weishaupt, T. J. Dougherty (1997) A quantitative structure-activity relationship for a congeneric series of pyropheophorbide derivatives as photosensitizers for photodynamic therapy. Cancer Res, 57, 4000–4007. CASPubMedWeb of Science®Google Scholar 15 Furukawa, K., D. H. Crean, T. S. Mang, H. Kato, T. J. Dougherty (1995) Fluorescence detection of premalignant, malignant, and micrometastatic disease using hexylpyropheophorbide. Proc. SPIE, 2371, 510–514. 10.1117/12.203403 Web of Science®Google Scholar 16 Lakowicz, J., K. Berndt (1991) Lifetime-selective fluorescence imaging using an rf sensitive camera. Rev. Sci. Instrum, 62, 1727–1734. 10.1063/1.1142413 CASWeb of Science®Google Scholar 17 Sevick, E. M., J. R. Lakowicz, H. Szmacinski, K. Nowaczyk, M. Johnson 1992 Frequency-domain imaging of obscure absorbers: principles and applications J. Photochem. Photobiol. B: Biol 16 169–185 10.1016/1011-1344(92)80007-I CASPubMedWeb of Science®Google Scholar 18 Eppstein, M. J., D. E. Dougherty, T. L. Troy, E. M. Sevick-Muraca (1999) Biomedical optical tomography using dynamic parameterization and Bayesian conditioning on photon migration measurements. Appl. Opt, 38, 2138–2150. 10.1364/AO.38.002138 CASPubMedWeb of Science®Google Scholar 19 Paithankar, D. Y., A. U. Chen, B. W. Pogue, M. S. Patterson, E. M. Sevick-Muraca (1997) Imaging of fluorescent yield and lifetime from multiply scattered light re-emitted from tissues and other random media. Appl. Opt, 36, 2260–2272. 10.1364/AO.36.002260 CASPubMedWeb of Science®Google Scholar 20 Hasan, T., J. A. Parrish 1997 Photodynamic therapy of cancer In Cancer Medicine, Vol. 1, 4th ed. (Edited by J. F. Holland, E. Frei, R. C. Bast, D. W. Kufe, D. L. Morton and R. R. Weichselbaum), pp. 739–751. Williams & Wilkins, Philadelphia Google Scholar 21 Schafer, K. A., G. Kelly, R. Schrader, W. C. Griffith, B. A. Muggenburg, L. A. Tierney, J. F. Lechner, E. B. Janovitz, F. F. Hahn (1998) A canine model of familial mammary gland neoplasia. Vet. Pathol, 35, 168–177. 10.1177/030098589803500302 CASPubMedWeb of Science®Google Scholar Citing Literature Volume72, Issue1July 2000Pages 94-102 ReferencesRelatedInformation
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