Developmental Neurotransmitters?
2002; Cell Press; Volume: 36; Issue: 6 Linguagem: Inglês
10.1016/s0896-6273(02)01136-4
ISSN1097-4199
AutoresDavid F. Owens, Arnold R. Kriegstein,
Tópico(s)Ion channel regulation and function
ResumoPrevious studies support an early role for neurotransmitter signaling before synaptogenesis, but puzzlingly, a neurological phenotype is absent in embryonic mice that lack vesicular release. Demarque et al. (in this issue of Neuron) now report that early release of transmitter is unconventional in not requiring action potentials, Ca(2+) entry, or vesicle fusion, thus potentially reconciling the discrepancy.
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