Stereoselective Total Synthesis of (−)‐Borrelidin
2004; Wiley; Volume: 116; Issue: 30 Linguagem: Inglês
10.1002/ange.200460203
ISSN1521-3757
AutoresBinh G. Vong, Sun Hee Kim, Sunny Abraham, Emmanuel A. Theodorakis,
Tópico(s)Asymmetric Synthesis and Catalysis
ResumoAngewandte ChemieVolume 116, Issue 30 p. 4037-4041 Zuschrift Stereoselective Total Synthesis of (−)-Borrelidin† Binh G. Vong, Binh G. Vong Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, MC: 0358, La Jolla, CA 92093-0358, USA, Fax: (+1) 858-822-0386Search for more papers by this authorSun Hee Kim, Sun Hee Kim Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, MC: 0358, La Jolla, CA 92093-0358, USA, Fax: (+1) 858-822-0386Search for more papers by this authorSunny Abraham, Sunny Abraham Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, MC: 0358, La Jolla, CA 92093-0358, USA, Fax: (+1) 858-822-0386Search for more papers by this authorEmmanuel A. Theodorakis Prof., Emmanuel A. Theodorakis Prof. [email protected] Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, MC: 0358, La Jolla, CA 92093-0358, USA, Fax: (+1) 858-822-0386Search for more papers by this author Binh G. Vong, Binh G. Vong Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, MC: 0358, La Jolla, CA 92093-0358, USA, Fax: (+1) 858-822-0386Search for more papers by this authorSun Hee Kim, Sun Hee Kim Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, MC: 0358, La Jolla, CA 92093-0358, USA, Fax: (+1) 858-822-0386Search for more papers by this authorSunny Abraham, Sunny Abraham Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, MC: 0358, La Jolla, CA 92093-0358, USA, Fax: (+1) 858-822-0386Search for more papers by this authorEmmanuel A. Theodorakis Prof., Emmanuel A. Theodorakis Prof. [email protected] Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, MC: 0358, La Jolla, CA 92093-0358, USA, Fax: (+1) 858-822-0386Search for more papers by this author First published: 20 July 2004 https://doi.org/10.1002/ange.200460203Citations: 23 † In honor of Professor E. J. Corey, recipient of the 2004 Priestley Medal. Financial support from the NIH (CA 086079) is gratefully acknowledged. We also thank Dr. L. N. Zakharov and Dr. P. Gantzel (UCSD, X-ray Facility) for the reported crystallographic studies and Professor D. B. Ball, California State University, Chico, for a sample of natural borrelidin. Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Eine konvergente Synthese von (−)-Borrelidin (1), die auf den im Bild gekennzeichneten retrosynthetischen Spaltungen beruht, enthält als zentrale Elemente den Aufbau eines gespannten, eine Eninon-Einheit enthaltenden Makrolids und das regioselektive Einbringen einer Cyangruppe mithilfe einer neuartigen molybdänkatalysierten Hydrostannylierung des Alkins. 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