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Histone acetylation and X inactivation

1998; Wiley; Volume: 22; Issue: 1 Linguagem: Inglês

10.1002/(sici)1520-6408(1998)22

1520-6408

Ann M. Keohane, Jayne S. Lavender, Laura P. O’Neill, Bryan M. Turner,

Peptidase Inhibition and Analysis

Developmental GeneticsVolume 22, Issue 1 p. 65-73 Histone acetylation and X inactivation Ann M. Keohane, Ann M. Keohane Chromatin and Gene Expression Group, Department of Anatomy, University of Birmingham Medical School, Edgbaston, Birmingham, U.K.Search for more papers by this authorJayne S. Lavender, Jayne S. Lavender Chromatin and Gene Expression Group, Department of Anatomy, University of Birmingham Medical School, Edgbaston, Birmingham, U.K.Search for more papers by this authorLaura P. O'Neill, Laura P. O'Neill Chromatin and Gene Expression Group, Department of Anatomy, University of Birmingham Medical School, Edgbaston, Birmingham, U.K.Search for more papers by this authorBryan M. Turner, Corresponding Author Bryan M. Turner [email protected] Chromatin and Gene Expression Group, Department of Anatomy, University of Birmingham Medical School, Edgbaston, Birmingham, U.K.Chromatin and Gene Expression Group, Department of Anatomy, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, U.K.Search for more papers by this author Ann M. Keohane, Ann M. Keohane Chromatin and Gene Expression Group, Department of Anatomy, University of Birmingham Medical School, Edgbaston, Birmingham, U.K.Search for more papers by this authorJayne S. Lavender, Jayne S. Lavender Chromatin and Gene Expression Group, Department of Anatomy, University of Birmingham Medical School, Edgbaston, Birmingham, U.K.Search for more papers by this authorLaura P. O'Neill, Laura P. O'Neill Chromatin and Gene Expression Group, Department of Anatomy, University of Birmingham Medical School, Edgbaston, Birmingham, U.K.Search for more papers by this authorBryan M. Turner, Corresponding Author Bryan M. Turner [email protected] Chromatin and Gene Expression Group, Department of Anatomy, University of Birmingham Medical School, Edgbaston, Birmingham, U.K.Chromatin and Gene Expression Group, Department of Anatomy, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, U.K.Search for more papers by this author First published: 06 December 1998 https://doi.org/10.1002/(SICI)1520-6408(1998)22:1 3.0.CO;2-5Citations: 44AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract In mammals, the levels of X-linked gene products in males and females are equalised by the silencing, early in development, of most of the genes on one of the two female X chromosomes. Once established, the silent state is stable from one cell generation to the next. In eutherian mammals, the inactive X chromosome (Xi) differs from its active homologue (Xa) in a number of ways, including increased methylation of selected CpGs, replication late in S-phase, expression of the Xistgene with binding of Xist RNA and underacetylation of core histones. The latter is a common property of genetically inactive chromatin but, in the case of Xi, it is not clear whether it is an integral part of the silencing process or simply a consequence of some other property of Xi, such as late replication. The present review describes two approaches that address this problem. The first shows that Xi in marsupial mammals also contains underacetylated H4, even though its properties differ widely from those of the eutherian Xi. The continued presence of histone underacetylation on Xi in these evolutionarily distant mammals argues for its fundamental importance. The second approach uses mouse embryonic stem cells and places H4 deacetylation in a sequence of events leading to complete X inactivation. The results argue that histone underacetylation plays a role in the stabilisation of the inactive state, rather than in its initiation. Dev. Genet. 22:65–73, 1998. © 1998 Wiley-Liss, Inc. References Barr ML, Bertram EG (1949): A morphological distinction between neurones of male and female, and the behaviour of the nucleolar satellite during accelerated nucleoprotein synthesis. 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